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Quantification of Diabetes-induced Adherent Leukocytes in Retinal Vasculature
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Hypertensive leucocytosis.

Rolinda Rajkumari1, Deben Laishram2, Joshna Thiyam

  • 1Department of Physiology, Jawaharlal Nehru Institute of Medical Sciences, Imphal.

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|January 31, 2014
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Hypertension is linked to increased white blood cell (WBC) counts, suggesting an inflammatory component. This study found significantly higher total leucocyte count (TLC) and neutrophils in Indian hypertensive patients compared to controls.

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Area of Science:

  • Cardiovascular Medicine
  • Hematology
  • Immunology

Background:

  • Hypertension is a global health concern.
  • Previous studies suggest a link between elevated white blood cell (WBC) count and hypertension.
  • Limited research exists on this association within the Indian population.

Purpose of the Study:

  • To investigate the association between hypertension and total leucocyte count (TLC) and differential leucocyte count in an Indian population.
  • To determine if hypertensive patients exhibit increased inflammatory markers compared to normotensive individuals.

Main Methods:

  • A case-control study involving 27 hypertensive patients and 27 age/sex-matched normotensive controls.
  • Blood samples analyzed for total leucocyte count (TLC), differential leucocyte count (neutrophils, lymphocytes), and erythrocyte sedimentation rate (ESR).
  • Hypertension defined as systolic BP ≥ 140 mmHg, diastolic BP ≥ 90 mmHg, or antihypertensive medication use.

Main Results:

  • Hypertensive patients showed significantly higher TLC (7413.70 vs. 5236.30 cells/cmm) and neutrophil percentages (62.04% vs. 53.00%) compared to controls.
  • Lymphocyte percentages were significantly lower in hypertensives (34.37% vs. 39.11%).
  • Erythrocyte sedimentation rate (ESR) was significantly elevated in the hypertensive group (29.63 mm/hr vs. 21.15 mm/hr).

Conclusions:

  • The study indicates a significant increase in inflammatory markers, including TLC and neutrophils, in hypertensive patients.
  • Findings suggest that hypertension may have an underlying inflammatory basis.
  • Elevated inflammatory markers in hypertensive patients warrant further investigation into their role in disease pathogenesis.