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Updated: May 3, 2026

Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs
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Nanoemulsion-based delivery systems for polyunsaturated (ω-3) oils: formation using a spontaneous emulsification

Alessandro Gulotta1, Amir Hossein Saberi, Maria Cristina Nicoli

  • 1Biopolymers and Colloids Laboratory, Department of Food Science, University of Massachusetts-Amherst , Amherst, Massachusetts 01003, United States.

Journal of Agricultural and Food Chemistry
|January 31, 2014
PubMed
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Researchers developed a low-energy method to create stable nanoemulsions for omega-3 oils. This technique is ideal for incorporating beneficial oils into clear food, cosmetic, and pharmaceutical products.

Area of Science:

  • Food science
  • Materials science
  • Chemical engineering

Background:

  • Nanoemulsions are increasingly used for encapsulating lipophilic compounds.
  • Applications span food, personal care, cosmetics, and pharmaceuticals.
  • Polyunsaturated oils, like omega-3s, require effective delivery systems.

Purpose of the Study:

  • To fabricate nanoemulsions using a spontaneous emulsification method.
  • To investigate the impact of various factors on nanoemulsion formation and stability.
  • To assess the potential for incorporating omega-3 oils into clear products.

Main Methods:

  • Utilized a low-energy spontaneous emulsification technique.
  • Fabricated nanoemulsions using fish oil as the polyunsaturated oil source.

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  • Varied surfactant-to-oil ratio (SOR), oil composition (lemon oil, MCT), and cosolvent composition (glycerol, ethanol, propylene glycol, water).
  • Main Results:

    • Optically transparent nanoemulsions were successfully formed.
    • Nanoemulsion characteristics were controllable by adjusting SOR and composition.
    • The spontaneous emulsification method proved effective for omega-3 oil encapsulation.

    Conclusions:

    • The spontaneous emulsification method is a viable low-energy approach for nanoemulsion fabrication.
    • This method offers significant potential for incorporating polyunsaturated oils into clear consumer products.
    • Optimized formulation parameters are key to achieving stable, transparent nanoemulsions.