Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Biofilms01:29

Biofilms

2.1K
Biofilms are complex communities of microorganisms encased in a self-produced extracellular polysaccharide matrix attached to surfaces. These microbial consortia can include single or multiple species, providing enhanced survival benefits by forming organized, multilayered structures.The formation of biofilms occurs through four key stages: attachment, colonization, development, and dispersal.During attachment, free-swimming planktonic cells adhere to a surface, often facilitated by...
2.1K
Colonisation of Pathogens01:25

Colonisation of Pathogens

77
Pathogen colonization of host tissues is a critical step in the development of infectious diseases. Various pathogenic microorganisms, including bacteria, fungi, viruses, and protozoa, have evolved complex strategies to attach to, invade, and persist within host environments. These mechanisms enable pathogens to establish infections, evade immune responses, and resist antimicrobial treatments.Attachment to Host CellsIn bacteria, colonization typically begins with adherence to host epithelial...
77
Urinary Tract Infection II: Pathophysiology01:25

Urinary Tract Infection II: Pathophysiology

1.5K
The pathophysiology of urinary tract infections (UTIs) encompasses several progressive stages, beginning with bacterial colonization and culminating in potential systemic complications if untreated. UTIs are primarily initiated by bacteria, such as Escherichia coli, which often originate from the gastrointestinal tract and migrate to the urinary system through the periurethral area. This migration can occur via several routes, including improper hygiene practices, sexual activity, or...
1.5K
The Oral Microbiota01:27

The Oral Microbiota

90
The oral microbiome includes a complex ecosystem comprising over 700 microbial species, identified through genomic sequencing and culture-based analyses to date. This community includes a core microbiome, found universally among individuals, and a variable component influenced by environmental factors such as diet, lifestyle, and host genetics. Site-specific conditions, including oxygen gradients, pH levels, and nutrient availability, determine the spatial distribution of these microorganisms...
90
Bacterial Meningitis II: Pathophysiology01:26

Bacterial Meningitis II: Pathophysiology

24
Bacterial meningitis typically begins when pathogens such as Neisseria meningitidis and Streptococcus pneumoniae colonize the nasopharynx and invade the bloodstream. This process is facilitated by bacterial virulence factors, such as polysaccharide capsules, which resist phagocytosis and complement-mediated killing. Less commonly, bacteria reach the central nervous system via contiguous spread from infections like otitis media or sinusitis, through congenital or acquired dural defects, or...
24
Infection01:20

Infection

11.6K
When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
11.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sex Influences Penumbral Leukocyte Mobilization after Severe TBI.

Neurocritical care·2026
Same author

Impact of surgery and complications on GI recovery after SBO: Insights from the SnapSBO cohort.

Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland·2026
Same author

Dogma, data, and decision-making: a history of treatment for small-bowel obstruction.

World journal of emergency surgery : WJES·2026
Same author

TXA after severe TBI: Learning and memory benefits are prominent only in males.

The journal of trauma and acute care surgery·2026
Same author

Management and outcome variability in hernia-related small bowel obstruction: insights from the SnapSBO study.

BJS open·2025
Same author

Acute Respiratory Distress Syndrome in Trauma 2007-2019: Comprehensive Patient and Center-Level Retrospective Cohort Analysis.

Critical care medicine·2025

Related Experiment Video

Updated: May 3, 2026

Author Spotlight: Studying Host-Microbe Interactions in Wound Biofilm Formation
07:16

Author Spotlight: Studying Host-Microbe Interactions in Wound Biofilm Formation

Published on: June 16, 2023

4.0K

Biofilm: basic principles, pathophysiology, and implications for clinicians.

Michael R Hall1, Edward McGillicuddy, Lewis J Kaplan

  • 11 Department of Surgery, Yale School of Medicine , New Haven, Connecticut.

Surgical Infections
|January 31, 2014
PubMed
Summary
This summary is machine-generated.

Biofilms, microbial communities found everywhere, cause difficult-to-treat infections, especially with medical devices. New prevention and treatment strategies are emerging, highlighting the need for better surgical education on biofilms.

More Related Videos

Development of a Polymicrobial Colony Biofilm Model to Test Antimicrobials in Cystic Fibrosis
07:16

Development of a Polymicrobial Colony Biofilm Model to Test Antimicrobials in Cystic Fibrosis

Published on: September 20, 2024

1.8K
Three-dimensional Patterning of Engineered Biofilms with a Do-it-yourself Bioprinter
08:40

Three-dimensional Patterning of Engineered Biofilms with a Do-it-yourself Bioprinter

Published on: May 16, 2019

9.4K

Related Experiment Videos

Last Updated: May 3, 2026

Author Spotlight: Studying Host-Microbe Interactions in Wound Biofilm Formation
07:16

Author Spotlight: Studying Host-Microbe Interactions in Wound Biofilm Formation

Published on: June 16, 2023

4.0K
Development of a Polymicrobial Colony Biofilm Model to Test Antimicrobials in Cystic Fibrosis
07:16

Development of a Polymicrobial Colony Biofilm Model to Test Antimicrobials in Cystic Fibrosis

Published on: September 20, 2024

1.8K
Three-dimensional Patterning of Engineered Biofilms with a Do-it-yourself Bioprinter
08:40

Three-dimensional Patterning of Engineered Biofilms with a Do-it-yourself Bioprinter

Published on: May 16, 2019

9.4K

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Medical Devices

Background:

  • Biofilms are widespread microbial communities found in diverse environments.
  • They play a significant role in clinically relevant infections, particularly those associated with implanted medical devices.

Purpose of the Study:

  • To review advances in understanding biofilm structure and function.
  • To identify challenges and opportunities in diagnosing and treating biofilm-associated infections.
  • To assess the current state of surgical education regarding biofilms.

Main Methods:

  • A comprehensive review of relevant English-language literature was conducted.

Main Results:

  • Significant progress has been made in understanding biofilm formation and its role in infections of wounds, the oral cavity, urinary and gastrointestinal tracts, and devices.
  • Effective diagnosis of biofilm infections is possible, but treatment remains challenging due to inherent microbial resistance and host immune factors.
  • Biofilm-related education is currently underrepresented in surgical training curricula.

Conclusions:

  • Promising new methods for preventing and treating biofilm infections are anticipated.
  • Enhancing surgical education on biofilm prevention, diagnosis, and therapy is crucial.