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Updated: May 3, 2026

Chemotherapy-induced Vascular Toxicity - Real-time In vivo Imaging of Vessel Impairment
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Anti-cancer agent-induced nephrotoxicity

Hirotaka Fukasawa, Ryuichi Furuya, Hideo Yasuda

  • 1Renal Division, Department of Internal Medicine, Iwata City Hospital, 512-3 Ohkubo, Iwata, Shizuoka 438-8550 Japan. hfukasawaucsd@gmail.com.

Anti-Cancer Agents in Medicinal Chemistry
|January 31, 2014
PubMed

Insights

Cancer patients face kidney injury risks from treatments. This review details anti-cancer drug nephrotoxicity, covering incidence, symptoms, and management for better patient outcomes.

Area of Science:

  • Nephrology
  • Oncology
  • Pharmacology

Background:

  • Cancer patients are susceptible to renal injuries from both the disease and its treatments.
  • Nephrotoxicity is a significant adverse effect of anti-cancer therapies, leading to diverse renal dysfunctions.

Purpose of the Study:

  • To comprehensively review the incidence, clinical presentation, prevention, and management of anti-cancer agent-induced renal dysfunction.
  • To focus on both novel and traditional anti-cancer agents commonly used in clinical practice.

Main Methods:

  • Literature review of anti-cancer agents and their impact on renal function.
  • Analysis of mechanisms of renal injury caused by specific chemotherapy drugs.

Main Results:

  • Identified a range of renal abnormalities, including glomerular/tubular dysfunction, hypertension, and endocrine disturbances.
  • Discussed frequently used agents: bevacizumab, gefitinib, gemcitabine, imatinib, rituximab, trastuzumab, cisplatin, methotrexate, ifosfamide, and taxanes.

Conclusions:

  • Understanding the mechanisms of drug-induced nephrotoxicity is crucial for developing safer anti-cancer agents.
  • Effective management and prevention strategies are essential for mitigating renal complications in cancer patients.

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