Protocol for the examination of specimens from patients with pheochromocytomas and extra-adrenal paragangliomas
Ozgur Mete1, Arthur S Tischler, Ronald de Krijger
1From the Departments of Pathology (Drs Mete and Asa) and Medicine (Dr Ezzat), University Health Network, Toronto, Ontario, Canada; the Department of Pathology, Tufts Medical Center, Boston, Massachusetts (Dr Tischler); the Department of Pathology, Erasmus MC University Medical Center, Rotterdam, The Netherlands (Dr de Krijger); the Department of Molecular and Cellular Pathology, The University of Queensland, University of Queensland Centre for Clinical Research, Royal Brisbane and Women's Hospital, Herston, Brisbane, Australia (Dr McNicol); the Institute of Clinical Chemistry and Laboratory Medicine and Department of Medicine III, University of Dresden, Dresden, Germany (Dr Eisenhofer); and the Program in Reproductive and Adult Endocrinology, Eunice Kennedy Shriver National Institutes of Health, Bethesda, Maryland (Dr Pacak).
Abstract:
During the last decade there have been revolutionary breakthroughs in understanding the biology of pheochromocytomas and extra-adrenal paragangliomas. Discoveries of new susceptibility genes and genotype-phenotype correlations have led to the realization that appropriate patient care requires a complete integration of clinical, genetic, biochemical, imaging, and pathology findings. Clinical practice has in many cases not kept pace with the rate of discovery, underscoring a need for updated procedures for evaluation of patient specimens and reporting of data. We therefore propose a new synoptic reporting approach for pheochromocytomas and extra-adrenal paragangliomas that will provide clear and uniform information to pathologists and clinicians, in order to advance the diagnosis of these neoplasms and optimize patient care.
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