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Effect of pain in pediatric inherited neuropathies

Sindhu Ramchandren1, Mamta Jaiswal, Eva Feldman

  • 1From the Department of Neurology (S.R., E.F.), University of Michigan Medical Health System, Ann Arbor, MI; and Department of Neurology (M.J., M.S.), University of Iowa, Iowa City.

Neurology
|January 31, 2014
PubMed

Insights

Pain is common in children with Charcot-Marie-Tooth (CMT) disease, significantly impacting their quality of life. Ankle inflexibility, not neuropathy severity, appears to be a key factor associated with increased pain in pediatric CMT patients.

Area of Science:

  • Neurology
  • Pediatrics
  • Pain Management

Background:

  • Charcot-Marie-Tooth (CMT) disease is a group of inherited neuropathies affecting peripheral nerves.
  • Pain is a frequently reported symptom in CMT, but its prevalence and impact in children are not well understood.

Purpose of the Study:

  • To assess the prevalence and impact of pain in children diagnosed with Charcot-Marie-Tooth disease.
  • To identify factors associated with pain in pediatric CMT patients.

Main Methods:

  • A prospective cross-sectional study was conducted with 176 children (aged 2-18 years) with CMT disease.
  • Standardized pain assessments (Wong-Baker FACES Pain Rating Scale), clinical evaluations, and quality-of-life (QOL) outcomes were collected.
  • Multivariate regression models were used to analyze the relationship between pain scores and neuropathy severity, functional impact, and foot structure.

Main Results:

  • The mean pain score was 2 (on a 0-5 scale), indicating a notable presence of pain.
  • Increased pain strongly correlated with worse QOL scores.
  • Ankle inflexibility was identified as an independent determinant of increased pain, while neuropathy severity did not show a significant correlation.

Conclusions:

  • Pain is a significant issue for children with CMT disease, negatively affecting their QOL.
  • Pain levels in pediatric CMT are not directly correlated with neuropathy severity.
  • Further research into pain mechanisms is needed to develop effective treatments for pain and improve QOL in children with CMT.
Abstract

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