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Related Experiment Videos

Serum acute phase reactants in necrotizing enterocolitis.

D Isaacs1, J North, D Lindsell

  • 1Department of Paediatrics, John Radcliffe Hospital, Headington, Oxford, UK.

Acta Paediatrica Scandinavica
|November 1, 1987
PubMed
Summary
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Serum C-reactive protein (CRP) levels significantly increase in infants with necrotizing enterocolitis (NEC). Elevated CRP within 48 hours aids in diagnosing NEC, showing high sensitivity and specificity.

Area of Science:

  • Biochemistry
  • Neonatal Medicine
  • Pediatric Surgery

Background:

  • Necrotizing enterocolitis (NEC) is a serious gastrointestinal condition in infants.
  • Early diagnosis and management of NEC are crucial for improving outcomes.
  • Biomarkers for NEC detection are actively sought.

Purpose of the Study:

  • To evaluate the utility of serum acute phase reactants, specifically C-reactive protein (CRP) and orosomucoid, in diagnosing NEC.
  • To determine the sensitivity and specificity of CRP in identifying definite NEC cases.

Main Methods:

  • Prospective study comparing serum CRP and orosomucoid levels in infants with and without NEC.
  • Analysis of CRP levels within 24-48 hours of presentation.
  • Correlation of CRP levels with clinical outcomes, including surgical complications.

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Main Results:

  • Infants with definite NEC showed significantly elevated CRP and orosomucoid levels within 24-48 hours.
  • A serum CRP threshold of >10 mg/l within 48 hours demonstrated 92% sensitivity and 81% specificity for definite NEC.
  • Elevated CRP persisted in infants with late-onset sepsis, abscess, or stricture requiring surgery.

Conclusions:

  • Serum acute phase reactants, particularly CRP, are valuable adjuncts for clinical assessment in suspected NEC.
  • CRP can aid in early identification of NEC and potential complications.
  • Monitoring CRP levels may assist in managing infants with suspected or confirmed NEC.