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Updated: May 3, 2026

Author Spotlight: Regenerative Peripheral Nerve Interface (RPNI) Surgery in Postamputation Pain Management
Published on: March 15, 2024
Amputation neuroma growing intravascularly into a thrombus
Wade L Schulz1, J Carlos Manivel2
1University of Minnesota Medical School, Minneapolis, MN, USA.
Amputation neuromas, typically benign nerve tumors, were found within a patient's artery. This rare case highlights unusual intravascular growth of nerve tissue following sarcoma amputation.
Area of Science:
- Surgical pathology
- Oncology
- Vascular surgery
Background:
- A patient with a history of sarcoma underwent arm amputation.
- Five years post-amputation, the patient experienced persistent pain and presented with radiologically detected masses.
Observation:
- Surgical exploration was performed due to the patient's symptoms and imaging findings.
- Microscopic examination revealed the masses to be amputation neuromas.
Findings:
- One amputation neuroma was discovered within the lumen of an artery.
- This neuroma was situated within a remote, organized thrombus.
Implications:
- This case represents the first documented instance of intravascular growth of an amputation neuroma.
- The findings suggest potential complications and unusual presentations following limb amputation for sarcoma.
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