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Updated: May 3, 2026

A11-positive β-amyloid Oligomer Preparation and Assessment Using Dot Blotting Analysis
Published on: May 22, 2018
Cyclic peptides as inhibitors of amyloid fibrillation
Jinghui Luo1, Jan Pieter Abrahams
1Leiden Institute of Chemistry, Leiden University, Gorlaeus Laboratoriesm, Einsteinweg 55 (The Netherlands).
Abstract:
Many neurodegenerative diseases, like Parkinson's, Alzheimer's, or Huntington's disease, occur as a result of amyloid protein fibril formation and cell death induced by this process. Cyclic peptides (CPs) and their derivatives form a new class of powerful inhibitors that prevent amyloid fibrillation and decrease the cytotoxicity of aggregates. The strategies for designing CPs are described, with respect to their amino acid sequence and/or conformational similarity to amyloid fibrils. The implications of CPs for the study and possible treatment of amyloid-related diseases are discussed.
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