Silver-coated monolithic columns for separation in radiopharmaceutical applications
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Published on: December 20, 2024
Ondrej Sedlacek1, Jan Kucka, Frantisek Svec
1Institute of Macromolecular Chemistry of the Academy of Sciences of the Czech Republic, Public Research Institution, Prague, Czech Republic; The Molecular Foundry, E. O. Lawrence Berkeley National Laboratory, Berkeley, CA, USA.
Abstract:
In this study, we demonstrate the preparation of a macroporous monolithic column containing anchored silver nanoparticles and its use for the elimination of excess radioiodine from the radiolabeled pharmaceutical. The poly(glycidyl methacrylate-co-ethylene dimethacrylate) monolith was first functionalized with cystamine and the free thiol groups liberated by reaction with borohydride. In-house-prepared silver nanoparticles were then attached by interaction with the surface thiols. The deiodization process was demonstrated with the commonly used radiopharmaceutical m-iodobenzylguanidine labeled with radionuclide iodine-125.
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