Silver-coated monolithic columns for separation in radiopharmaceutical applications

Area of Science:

• Materials Science
• Radiochemistry
• Nanotechnology

Background:

• Radiolabeled pharmaceuticals are crucial in medical imaging and therapy.
• Ensuring the purity of radiopharmaceuticals by removing excess radioiodine is essential for safety and efficacy.
• Current methods for radioiodine removal may have limitations in efficiency or applicability.

Purpose of the Study:

• To develop a macroporous monolithic column with anchored silver nanoparticles.
• To evaluate the column's effectiveness in eliminating excess radioiodine from radiolabeled pharmaceuticals.
• To demonstrate the application of this technology using a common radiopharmaceutical.

Main Methods:

• Preparation of a poly(glycidyl methacrylate-co-ethylene dimethacrylate) macroporous monolithic column.
• Functionalization of the monolith with cystamine and subsequent thiol group liberation.
• Anchoring of in-house-prepared silver nanoparticles onto the functionalized monolith surface.
• Demonstration of deiodization using m-iodobenzylguanidine labeled with iodine-125.

Main Results:

• Successful preparation of a macroporous monolithic column with anchored silver nanoparticles.
• Demonstrated efficient elimination of excess radioiodine from the radiolabeled pharmaceutical.
• The method proved effective for the deiodization of m-iodobenzylguanidine (¹²⁵I).

Conclusions:

• A novel macroporous monolithic column functionalized with silver nanoparticles is a viable tool for radioiodine removal.
• This approach offers a promising method for purifying radiolabeled pharmaceuticals.
• The developed material and method contribute to enhancing the safety and quality of radiopharmaceuticals.