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Published on: October 11, 2018
Sleep and protein synthesis-dependent synaptic plasticity: impacts of sleep loss and stress
Janne Grønli1, Jonathan Soulé2, Clive R Bramham3
1Department of Biological and Medical Psychology, University of Bergen Bergen, Norway ; Norwegian Competence Center for Sleep Disorders, Haukeland University Hospital Bergen, Norway.
Abstract:
Sleep has been ascribed a critical role in cognitive functioning. Several lines of evidence implicate sleep in the consolidation of synaptic plasticity and long-term memory. Stress disrupts sleep while impairing synaptic plasticity and cognitive performance. Here, we discuss evidence linking sleep to mechanisms of protein synthesis-dependent synaptic plasticity and synaptic scaling. We then consider how disruption of sleep by acute and chronic stress may impair these mechanisms and degrade sleep function.
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