Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Transient and Steady-state Response01:24

Transient and Steady-state Response

756
In control systems, test signals are essential for evaluating performance under various conditions. The ramp function is effective for systems undergoing gradual changes, while the step function is suitable for assessing systems facing sudden disturbances. For systems subjected to shock inputs, the impulse function is the most appropriate test signal.
These test signals are integral in designing control systems to exhibit two key performance aspects: transient response and steady-state...
756
Types of Selection01:46

Types of Selection

37.5K
Natural selection influences the frequencies of particular alleles and phenotypes within populations in several different ways. Primarily, natural selection can be directional, stabilizing, or disruptive. Directional selection favors one extreme trait and shifts the population towards that phenotype while selecting against individuals displaying alternate traits. Stabilizing selection favors an intermediate trait with a narrow range of variation. Deviation from the optimal phenotype towards an...
37.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Chronic alcohol-induced brain states limit propagation of direct cortical stimulation.

Scientific reports·2025
Same author

Distinct Alpha Connectivity Patterns During Response Inhibition in Alcohol Use Disorder.

Human brain mapping·2025
Same author

Metacontrol is reflected in phasic but not tonic cognitive control dynamics.

Scientific reports·2025
Same author

Uncertainty, Cognitive Control and Theta-Band Activity: A Relationship That Depends on Metacontrol Requirements.

Human brain mapping·2025
Same author

The Dynamic Management of Working Memory Is Supported by Aperiodic Neural Activity.

Psychophysiology·2025
Same author

Distinct roles of alpha and theta oscillations in information-seeking in cognitive control.

Journal of neurophysiology·2025

Related Experiment Video

Updated: May 3, 2026

Presynaptic Dopamine Dynamics in Striatal Brain Slices with Fast-scan Cyclic Voltammetry
08:49

Presynaptic Dopamine Dynamics in Striatal Brain Slices with Fast-scan Cyclic Voltammetry

Published on: January 12, 2012

21.5K

Transient and steady-state selection in the striatal microcircuit.

Adam Tomkins1, Eleni Vasilaki1, Christian Beste2

  • 1Department of Computer Science, University of Sheffield Sheffield, UK ; INSIGNEO Institute for in Silico Medicine, University of Sheffield Sheffield, UK.

Frontiers in Computational Neuroscience
|January 31, 2014
PubMed
Summary

The striatal microcircuit generates a transient signal that aids action selection in the brain. This novel mechanism may explain cognitive improvements observed in Huntington's disease patients.

Keywords:
Huntington's diseaseaction selectionbasal gangliaexcitotoxicityresponse selectionstriatum

More Related Videos

New Variations for Strategy Set-shifting in the Rat
09:45

New Variations for Strategy Set-shifting in the Rat

Published on: January 23, 2017

7.7K
Modeling Fast-scan Cyclic Voltammetry Data from Electrically Stimulated Dopamine Neurotransmission Data Using QNsim1.0
07:41

Modeling Fast-scan Cyclic Voltammetry Data from Electrically Stimulated Dopamine Neurotransmission Data Using QNsim1.0

Published on: June 5, 2017

8.9K

Related Experiment Videos

Last Updated: May 3, 2026

Presynaptic Dopamine Dynamics in Striatal Brain Slices with Fast-scan Cyclic Voltammetry
08:49

Presynaptic Dopamine Dynamics in Striatal Brain Slices with Fast-scan Cyclic Voltammetry

Published on: January 12, 2012

21.5K
New Variations for Strategy Set-shifting in the Rat
09:45

New Variations for Strategy Set-shifting in the Rat

Published on: January 23, 2017

7.7K
Modeling Fast-scan Cyclic Voltammetry Data from Electrically Stimulated Dopamine Neurotransmission Data Using QNsim1.0
07:41

Modeling Fast-scan Cyclic Voltammetry Data from Electrically Stimulated Dopamine Neurotransmission Data Using QNsim1.0

Published on: June 5, 2017

8.9K

Area of Science:

  • Neuroscience
  • Computational Neuroscience
  • Systems Neuroscience

Background:

  • The basal ganglia are crucial for action selection, but the striatum's specific role remains unclear.
  • Existing models lack a detailed understanding of the striatal microcircuit's contribution to decision-making.
  • Basal ganglia-thalamo-cortical loops are fundamental to motor control and cognitive functions.

Purpose of the Study:

  • To investigate the computational role of the striatal microcircuit in action selection.
  • To model the dynamic interactions within the basal ganglia-thalamo-cortical circuit.
  • To explore potential mechanisms underlying cognitive changes in Huntington's disease.

Main Methods:

  • Developed a large-scale 3D spiking model of the striatum.
  • Integrated the striatal model with a rate-coded model of the basal ganglia-thalamo-cortical loop.
  • Simulated and analyzed transient phenomena and their impact on decision-making.

Main Results:

  • Identified a transient phenomenon in the striatal microcircuit that enhances differences between competing inputs.
  • Demonstrated that this transient selection sufficiently modulates decision-making in the circuit.
  • Discovered a novel adaptation effect in striatal projection neurons responsible for transient selection.

Conclusions:

  • The striatal microcircuit actively contributes to action selection via a transient enhancement mechanism.
  • This transient selection model offers a potential explanation for paradoxical cognitive improvements in Huntington's disease.
  • Findings suggest a new avenue for experimental investigation into striatal function and neurological disorders.