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Updated: May 3, 2026

Myeloid Innate Signaling Pathway Regulation by MALT1 Paracaspase Activity
Published on: January 7, 2019
Peptidoglycan in combination with muramyldipeptide synergistically induces an interleukin-10-dependent T helper
Katsuhiko Matsui1, Reiko Ikeda
1Department of Microbial Science and Host Defense, Meiji Pharmaceutical University, 2-522-1 Noshio Kiyose, Tokyo, 204-8588, Japan.
Abstract:
In this study, peptidoglycan (PEG) from Staphylococcus aureus-stimulated, but not muramyldipeptide (MDP)-stimulated, Langerhans cells (LCs) induced a dose-dependent Th2-prone immune response. However, when LCs were stimulated with PEG in combination with MDP, the strength of Th2 immune responses was synergistically augmented by MDP. Furthermore, it was found that production of IL-10, but not of IL-12 p40, by PEG-stimulated LCs was also enhanced in the presence of MDP. These results suggest that MDP enhances Th2 cell development through up-regulation of IL-10 production from PEG-stimulated LCs, increase the importance of S. aureus colonization in patients with atopic dermatitis.
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