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Vasospastic angina and Ca channel blockers

Shinya Minatoguchi1

  • 1Department of Cardiology, Gifu University Graduate School of Medicine, Gifu, Japan, Yanagido 1-1, Gifu, Gifu 501-1194, Japan. minatos@gifu-u.ac.jp.

Current Hypertension Reviews
|February 1, 2014
PubMed

Insights

Benidipine demonstrates superior outcomes for vasospastic angina (VSA) patients compared to other calcium channel blockers. This meta-analysis highlights benidipine

Area of Science:

  • Cardiology
  • Pharmacology
  • Clinical Medicine

Background:

  • Coronary artery spasm is a known cause of angina pectoris, acute myocardial infarction, and sudden cardiac death.
  • Calcium channel blockers (CCBs) are established treatments for vasospastic angina (VSA).
  • Optimal CCB selection for VSA prognosis remains unclear.

Purpose of the Study:

  • To compare the prognostic effects of four CCBs in VSA patients.
  • To identify the CCB with the best outcomes for VSA treatment.

Main Methods:

  • A meta-analysis was conducted.
  • Included CCBs: amlodipine, nifedipine, benidipine, and diltiazem.
  • Patient outcomes focused on major adverse cardiovascular events (MACE).

Main Results:

  • Benidipine demonstrated a statistically significant better prognostic effect on MACE.
  • This effect was superior when compared to amlodipine, nifedipine, and diltiazem.

Conclusions:

  • Benidipine offers a superior prognosis for VSA patients compared to amlodipine, nifedipine, and diltiazem.
  • This finding aids in optimizing CCB selection for VSA management.

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