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Related Concept Videos

Methods of Documentation II: POMR01:26

Methods of Documentation II: POMR

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The Problem-Oriented Medical Record (POMR) revolutionized medical record-keeping by introducing a systematic approach focusing on the patient's problems rather than merely listing symptoms. Dr. Lawrence Weed's introduction of this method in the 1960s marked a significant advancement in medical documentation. The POMR framework consists of four key components: the database, problem list, plan of care, and progress notes.
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Binding sites linkages can regulate a protein's function.  For example, enzyme activity is often regulated through a feedback mechanism where the end product of the biochemical process serves as an inhibitor.
Aspartate transcarbamoylase (ATCase) is a cytosolic enzyme that catalyzes the condensation of L-aspartate and carbamoyl phosphate to  N-carbamoyl-L-aspartate. This reaction is the first step in pyrimidine biosynthesis. UTP and CTP, the end products of the pyrimidine synthesis...
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The mammalian target of rapamycin  (mTOR) is a serine/threonine kinase that regulates growth, proliferation, and cell survival in response to hormones, growth factors, or nutrient availability. This kinase exists in two structurally and functionally distinct forms: mTOR complex 1  (mTORC1) and mTOR complex 2  (mTORC2). The first form (mTORC1) is composed of a rapamycin-sensitive Raptor and proline-rich Akt substrate, PRAS40. In contrast,  mTORC2 consists of a...
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mTOR Signaling and Cancer Progression03:03

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The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
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Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
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Cancer-Critical Genes I: Proto-oncogenes01:33

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Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
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Related Experiment Video

Updated: May 3, 2026

Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs
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Controversy: pomr-the case in favour.

M Rendall1

  • 1Senior Lecturer and Consultant Surgeon, Guy's Hospital and Medical School, St Thomas Street, London, SE1 9R T, UK.

Medical Teacher
|February 1, 2014
PubMed
Summary

Clinicians often neglect medical records, yet their absence causes significant stress for both doctors and patients. This highlights the paradoxical importance and underappreciation of clinical documentation.

Area of Science:

  • Medical Informatics
  • Clinical Documentation

Background:

  • Clinicians frequently express dissatisfaction with the current state of medical records.
  • The absence of patient notes during clinic visits is a common and stressful occurrence.

Purpose of the Study:

  • To explore the paradoxical role and perceived importance of medical records in clinical practice.
  • To analyze clinician attitudes towards medical documentation.

Main Methods:

  • Qualitative analysis of clinician experiences and attitudes.
  • Exploration of the consequences of missing medical records.

Main Results:

  • The study reveals a widespread reluctance among clinicians to engage with medical records.
  • Missing documentation leads to increased stress and inefficiency in patient care.

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  • Clinicians acknowledge the purpose of records but often treat them with indifference when available.
  • Conclusions:

    • Despite their unpopularity, medical records are essential for effective patient care.
    • There is a need to address the discrepancy between the acknowledged importance and actual utilization of clinical documentation.
    • Improving clinician engagement with medical records is crucial for reducing stress and enhancing healthcare delivery.