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Updated: May 3, 2026

Improving IV Insulin Administration in a Community Hospital
Published on: June 11, 2012
Perioperative intensive insulin therapy using an artificial endocrine pancreas with closed-loop glycemic control
Kazuhiro Hanazaki1, Hiroyuki Kitagawa1, Tomoaki Yatabe2
1Department of Surgery, Kochi Medical School, Kochi University, Kohasu, Okocho, Nankoku-City, Kochi 783-8505, Japan.
Background:
We examined whether perioperative intensive insulin therapy (IIT) using an artificial pancreas (AP) with a closed-loop glycemic control system can be used to prevent hypoglycemia in surgical patients.
Methods:
Between 2006 and 2012, perioperative glycemic control using an AP was performed in 427 patients undergoing general surgery. A total of 305 patients undergoing IIT using an AP in the target blood glucose range of 80 to 110 mg/dL were enrolled in the study. Data were collected prospectively and were reviewed or analyzed retrospectively.
Results:
No patients had hypoglycemia. Perioperative mean blood glucose level and achievement rates in target blood glucose range of 80 to 110 mg/dL were 100.5 ± 11.9 mg/dL and 88.1% ± 16.0%, respectively. For the 3 primary operative methods, including hepatic, pancreatic, and esophageal resections, there were no significant differences in glycemic control stability between the types of surgery.
Conclusion:
Perioperative IIT using an AP with a closed-loop glycemic control system can be used to prevent hypoglycemia and maintain stable glycemic control with less variability of blood glucose concentration.
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