Related Experiment Video
Updated: May 3, 2026
Stereotactic Radiosurgery for Gynecologic Cancer
Published on: April 17, 2012
Comparative analysis of rectal dose parameters in image-guided high-dose-rate brachytherapy for cervical cancer with
Marc Gaudet1, Peter Lim2, Conrad Yuen2
1Department of Radiation Oncology, BC Cancer Agency Vancouver Centre, Vancouver, BC, Canada; Département de radio-oncologie, CSSS de Gatineau-Hôpital de Gatineau, Gatineau, QC, Canada.
Purpose:
The objective of this study was to determine if use of a rectal retractor (RR) in high-dose-rate intracavitary brachytherapy for cervical cancer reduces rectal dose parameters.
Methods And Materials:
We reviewed data obtained from patients treated with intracavitary brachytherapy for cervical cancer with and without an RR. Treatment plans for each brachytherapy fraction were separated into two groups; R group with use of an RR and P group with use of vaginal packing. Dose-volume parameters for high-risk clinical target volume (HR-CTV), rectum, sigmoid, small bowel, and vaginal surface were collected for each fraction. Rectal D2cc and International Commission on Radiation Units & Measurements (ICRU) rectal point doses were compared between groups using Student's t tests. Predictors of higher rectal D2cc were determined by univariate and multivariate regression analyses.
Results:
Four hundred sixty-three brachytherapy fractions from 114 patients were used for analysis, 377 fractions with a RR (R group) and 86 with vaginal packing only (P group). Both groups were similar except for slightly higher mean HR-CTV and mean bladder volume in P group. Both mean ICRU rectal point dose (241.1 vs. 269.9 cGy, p = 0.006) and rectal D2cc (240.6 vs. 283.6 cGy, p < 0.001) were significantly higher in P group. Point A dose, HR-CTV, stage, and use of an RR were significant predictors of rectal D2cc on multivariate analysis.
Conclusions:
Our data show that use of an RR leads to lower rectal dose parameters compared with vaginal packing. Further study is needed to determine if this will lead to less long-term toxicity.
