Related Experiment Video
Updated: May 3, 2026
05:53
Use of In vivo Imaging to Monitor the Progression of Experimental Mouse Cytomegalovirus Infection in Neonates
Published on: July 6, 2013
14.3K
Borna disease virus infection in cats
Jonas Johansson Wensman1, Karin Hultin Jäderlund2, Bodil Ström Holst1
1Department of Clinical Sciences, Swedish University of Agricultural Sciences, P.O. Box 7054, SE-750 07 Uppsala, Sweden.
Veterinary Journal (London, England : 1997)
|February 1, 2014
Summary
Borna disease virus (BDV) causes neurological "staggering disease" in cats, characterized by ataxia and behavioral changes. This review details BDV in felines, covering causes, signs, spread, and diagnosis.
Area of Science:
- Veterinary Neurology
- Virology
- Infectious Diseases
Background:
- Bornaviruses are a genus of viruses known to induce neurological disorders across various animal species.
- Avian Bornavirus (ABV) is associated with proventricular dilatation disease (PDD) in birds, while Borna disease virus (BDV) affects horses and sheep, causing Borna disease.
- In cats, BDV manifests as a neurological condition often referred to as "staggering disease," presenting with symptoms like ataxia, altered behavior, and impaired postural reactions.
Purpose of the Study:
- To review and consolidate current knowledge regarding Borna disease virus (BDV) infections specifically in domestic cats.
- To provide a comprehensive overview of BDV in felines, encompassing the etiological agent, clinical manifestations, disease progression (pathogenesis), disease spread (epidemiology), and diagnostic methods.
- To draw comparisons between Borna disease virus infections in cats and Bornavirus infections observed in other animal species.
Main Methods:
- This review synthesizes existing scientific literature and research findings on Borna disease virus in cats.
- Information was gathered from global reports on BDV infection markers in feline populations.
- Comparative analysis was performed between feline Bornavirus infections and those in other species.
Main Results:
- Borna disease virus (BDV) is a recognized cause of neurological illness in cats, globally reported.
- Clinical signs in affected cats include ataxia, significant behavioral changes, and loss of postural reactions.
- Evidence of BDV infection in cats has been documented worldwide, indicating a broad geographical distribution.
Conclusions:
- Borna disease virus poses a significant neurological threat to cats, with worldwide prevalence.
- Understanding the clinical signs, pathogenesis, epidemiology, and diagnostics of BDV in cats is crucial for effective management and control.
- Comparative insights from Bornavirus infections in other species can inform our understanding of the disease in felines.
More Related Videos
Related Concept Videos
01:27Cytomegalovirus Disease
102
Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...
102
01:51Mechanisms of Retrovirus-induced Cancers
5.2K
Retroviruses are RNA viruses that have been shown to cause cancers in diverse species, including chickens, mice, cats, and monkeys. The RNA genomes of these viruses are first reverse-transcribed into single and then double-stranded DNA (dsDNA) copies. This dsDNA called proviral DNA then integrates into the host genome. Subsequently, the host cell transcribes the proviral DNA in concert with the chromosomal DNA. This leads to the production of viral RNA and proteins that assemble at the host...
5.2K
01:10Retrovirus Life Cycles
43.0K
Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the...
43.0K