Differences in bone remodeling using demineralized bone matrix in bilateral sagittal split ramus osteotomy: a study...

Area of Science:

• Oral and Maxillofacial Surgery
• Regenerative Medicine
• Biomaterials Science

Background:

• Sagittal split ramus osteotomy (SSRO) is a common orthognathic procedure.
• Bone grafting is often necessary to manage large bony gaps and ensure stability.
• Demineralized bone matrix (DBM) is a potential osteoconductive material for bone regeneration.

Purpose of the Study:

• To evaluate the effect of demineralized bone matrix (DBM) grafts on bone remodeling after SSRO.
• To compare bone volume changes in patients receiving DBM grafts versus those without grafts.
• To assess the utility of 3D-CBCT imaging for volumetric analysis in SSRO.

Main Methods:

• A prospective study involving 48 patients undergoing SSRO.
• Control group: no graft. DBM group: DBX graft placed between segments.
• 3D-CBCT scans at baseline, 3 months (T2), and 6 months (T3) post-surgery.
• Volumetric analysis using SimPlant software to calculate bone volume-increasing ratio.

Main Results:

• Both groups showed significant bone volume increase.
• The DBM group exhibited a significantly higher volume-increasing ratio compared to the control group.
• Bone volume increase was sustained until 6 months post-surgery in the DBM group, whereas the control group showed minimal increase after 3 months.

Conclusions:

• DBM grafting is a beneficial procedure in orthognathic surgery, accelerating bone formation and enhancing segment stability.
• DBM grafts can effectively manage large bony gaps, reduce healing time, and prevent postoperative complications.
• Volumetric analysis with 3D-CBCT is a practical and efficient method for assessing bone healing post-SSRO.