Orbital metastasis as the inaugural presentation of occult rectal cancer
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Updated: May 3, 2026

Orthotopic Mouse Model of Colorectal Cancer
Published on: December 4, 2007
Eya Cherif1, Lamia Ben Hassine, Samira Azzabi
1Faculty of Medicine, Department of Internal Medicine, Charles Nicolle's Hospital, University of Tunis El Manar, Tunis, Tunisia.
Abstract:
Orbital metastasis is uncommon and occurs in 2-3% of patients with cancer. It is rarely the initial manifestation of a systemic malignancy. It usually indicates extensive haematogenous dissemination of a primary cancer and is associated with poor prognosis. Breast, lungs and prostate cancers are the most common primary cancers leading to orbital metastasis. However, orbital tumour revealing a rectal adenocarcinoma is exceptional. We describe a case of orbital tumour in a 67-year-old man with no history of systemic cancer while presenting with ophthalmic symptoms. Investigations revealed rectal adenocarcinoma as the primary malignant tumour.
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