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Related Experiment Video

Updated: May 3, 2026

A Standardized Obstacle Course for Assessment of Visual Function in Ultra Low Vision and Artificial Vision

A Standardized Obstacle Course for Assessment of Visual Function in Ultra Low Vision and Artificial Vision

Published on: February 11, 2014

Assessing residual visual function in severe vision loss.

Lauren N Ayton¹, Nicholas V Apollo, Mary Varsamidis

¹Centre for Eye Research Australia, The University of Melbourne, Royal Victorian Eye and Ear Hospital, East Melbourne, Victoria, Australia.

Investigative Ophthalmology & Visual Science

|February 1, 2014

Summary

This summary is machine-generated.

Assessing residual vision in severe vision loss requires multiple tests. Goldman visual field (GVF) and electroretinography (ERG) can detect some function, but structural imaging may not always align, necessitating multimodal assessment.

Keywords:

electroretinography low vision retinitis pigmentosa vision regeneration visual function

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Last Updated: May 3, 2026

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Assessing Binocular Central Visual Field and Binocular Eye Movements in a Dichoptic Viewing Condition

Assessing Binocular Central Visual Field and Binocular Eye Movements in a Dichoptic Viewing Condition

Published on: July 21, 2020

Area of Science:

Ophthalmology
Neuroscience
Medical Imaging

Background:

Vision restoration treatments are emerging for profound vision loss.
Accurate assessment of residual visual function is crucial for determining treatment efficacy.
Multimodal assessment strategies are needed to comprehensively evaluate retinal structure and function.

Purpose of the Study:

To compare residual visual function detected by Goldman visual field (GVF) and full-field electroretinography (ffERG).
To correlate these functional measures with the remaining photoreceptor layer assessed by spectral-domain optical coherence tomography (SD-OCT).
To evaluate these parameters in subjects with severe vision loss, specifically advanced retinitis pigmentosa.

Main Methods:

Fifty-four subjects with advanced retinitis pigmentosa and undetectable ffERG signals were included.
Residual function was assessed using discrete Fourier transform (DFT) analysis of the 30-Hz flicker ffERG and percentage of remaining GVF.
The horizontal extent of the outer nuclear layer (ONL) was measured using SD-OCT.

Main Results:

A 30-Hz flicker response was detected in 30% of eyes via DFT analysis of ffERG.
A measurable GVF was present in 57% of eyes.
A visible ONL was observed in 35% of eyes via SD-OCT.
No significant correlation was found between ffERG response magnitude and GVF (r=0.172, P=0.213) or photoreceptor extent (r=0.258, P=0.06).
Only 17% of eyes showed detectable results across all three parameters (ffERG, GVF, ONL).

Conclusions:

DFT analysis of 30-Hz flicker ffERG and GVF can detect trace residual function in severe vision loss.
The presence of residual function may not always be supported by structural evidence (measurable ONL).
Multimodal assessment combining structural and functional tests is essential for accurately defining retinal parameters in individuals with profound vision loss.