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Updated: Dec 25, 2025

Author Spotlight: Experimental Approaches for the Synthesis of Low-Valent Metal-Organic Frameworks from Multitopic Phosphine Linkers
Published on: May 12, 2023
Transition metal-promoted biomimetic steps in total syntheses
1Muséum National d'Histoire Naturelle and Centre National de la Recherche Scientifique, Unité"Molécules de Communication et Adaptation des Micro-organismes" (UMR 7245 CNRS-MNHN), 57 rue Cuvier (CP 54), 75005 Paris, France. bnay@mnhn.fr.
Abstract:
This review summarizes the state-of-the-art on the use of transition metals in synthetic steps inspired by biosynthesis. After an introduction showing the importance of metals in life processes, with special emphasis on biosynthetic processes, their place in biomimetic synthesis will be described. Topics include oxidative cyclizations for polyether synthesis, electrophilic and radical cyclizations of polyprenoids, the role of palladium in electrocyclizations, oxidative biaryl couplings and other rearrangement steps.
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