Related Experiment Video
Updated: May 3, 2026

Orthotopic Injection of Breast Cancer Cells into the Mice Mammary Fat Pad
Published on: January 20, 2019
Orbital amyloidosis masquerading as metastatic breast carcinoma
Ann P Murchison1, Jurij R Bilyk, Peter J Savino
1*Skull Base Division, Neuro-Ophthalmology Service, Wills Eye Institute, Philadelphia, Pennsylvania; and †Department of Ophthalmology, Shiley Eye Center, University of California San Diego, La Jolla, California, U.S.A.
Abstract:
One of the most common causes of enophthalmos is previous orbital fracture. In a patient with a known history of breast carcinoma, enophthalmos is concerning for metastatic disease. This report presents a patient with a history of scirrhous breast carcinoma and enophthalmos who was found to have orbital amyloidosis. This is the first report of enophthalmos as the presenting sign of orbital amyloidosis.

