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Epidemiology of GB virus type C among patients infected with HIV in Singapore

Chun Kiat Lee1, Julian Wei-Tze Tang, Lily Chiu

  • 1Molecular Diagnosis Centre, Department of Laboratory Medicine, National University Hospital, Singapore.

Journal of Medical Virology
|February 1, 2014
PubMed

Insights

GB virus type C (GBV-C) and human immunodeficiency virus (HIV) co-infection was found in 10% of HIV patients in Singapore. This study identified common GBV-C genotypes and suggests further research into the clinical impact of co-infection.

Area of Science:

  • Virology
  • Epidemiology
  • Infectious Diseases

Background:

  • GB virus type C (GBV-C) co-infection with human immunodeficiency virus (HIV) is associated with slower acquired immunodeficiency syndrome (AIDS) progression and increased lifespan.
  • Limited data exists on GBV-C/HIV co-infection prevalence in Singapore's growing HIV population.

Purpose of the Study:

  • To determine the prevalence of GBV-C co-infection among HIV-1-positive patients in Singapore.
  • To identify the genotypes of GBV-C circulating in this co-infected population.

Main Methods:

  • Screening of 80 archived HIV-1-positive samples from National University Hospital using two GBV-C assays.
  • Phylogenetic analysis of GBV-C isolates from co-infected patients.

Main Results:

  • The overall prevalence of GBV-C/HIV co-infection was 10% (8/80).
  • Predominant GBV-C genotypes identified were genotype 3 (50%) and genotype 2a (25%).
  • Genotypes 2b and 4, previously undescribed in Singapore, were also identified in single cases.

Conclusions:

  • GBV-C co-infection is present in Singaporean HIV patients, with specific genotypes circulating.
  • The findings highlight the complex epidemiology of GBV-C in co-infected individuals.
  • Larger studies are needed to fully characterize GBV-C co-infection and its clinical implications in HIV patients.

Keywords:
GBV-CHIV-1genotypehepatitis Gphylogenetic analysis

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