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Updated: May 3, 2026
Isolation, Culture, and Differentiation of Bone Marrow Stromal Cells and Osteoclast Progenitors from Mice
Published on: January 6, 2018
Bone marrow stromal cell assays: in vitro and in vivo
Pamela Gehron Robey1, Sergei A Kuznetsov1, Mara Riminucci2
1National Institute of Dental and Craniofacial Research, NIH, Bethesda, MD, USA.
Abstract:
Populations of bone marrow stromal cells (BMSCs, also known as bone marrow-derived "mesenchymal stem cells") contain a subset of cells that are able to recapitulate the formation of a bone/marrow organ (skeletal stem cells, SSCs). The biological properties of BMSC cultures are assessed by a variety of assays, both in vitro and in vivo. Application of these assays in an appropriate fashion provides a great deal of information on the role of BMSCs, and the subset of SSCs, in health and in disease.
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