Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Adaptability of Cytoskeletal Filaments01:12

Adaptability of Cytoskeletal Filaments

5.7K
The cytoskeleton is a complex dynamic structure performing varied functions based on cellular requirements. The adaptability of the individual filaments in the cytoskeleton determines their ability to perform various functions within the cell. It can undergo rapid reorganization during processes like cell division or remain stable for several hours as in the interphase. The adaptability of these filaments depends on stringent regulatory mechanisms. The microfilament and microtubules of the...
5.7K
Studying the Cytoskeleton01:17

Studying the Cytoskeleton

8.3K
The cytoskeletal architecture can be studied using different microscopic and biochemical techniques. Electron microscopy was instrumental in discovering the cytoskeletal architecture around the 1960s, which allowed obtaining structural information at a high-resolution level. However, the sample preparation procedure often limits this ability in biological samples. Several protocols have been developed over the years to optimize sample preparation. In one of the protocols known as rotary...
8.3K
Centrioles and Centrosomes01:13

Centrioles and Centrosomes

6.9K
Most animal cells comprise a pair of centrioles together called a centrosome. The cell duplicates its centrosome and contains two centrosomes side-by-side, which begin to move apart during the prophase. As the centrosomes migrate to two different sides of the cell, microtubules start extending from each centrosome toward the other end. The mitotic spindle is composed of the centrosomes and their emerging microtubules.
Near the end of the prophase, also called late prophase or...
6.9K
Distribution of Cytoplasmic Content02:33

Distribution of Cytoplasmic Content

3.3K
Cytokinesis segregates a cell’s chromosomes and organelles into its daughter cells. Organelles divide and grow prior to cell division but cannot be synthesized de novo; therefore, cells must receive at least one copy of each organelle to survive. Currently, many of the details of how the organelles are distributed are not yet fully elucidated.
Distribution of cytoplasmic determinants
The cytoplasm contains various organelles, as well as salts, proteins, and water. The distribution of...
3.3K
Introduction to the Cytoskeleton01:33

Introduction to the Cytoskeleton

24.8K
Overview of the Cytoskeleton
The cytoskeleton is a network of protein filaments present within the cell, having three distinct filaments ̶   microfilaments, microtubules, and intermediate filaments. Each has characteristic features that distinguish them, including the dynamics of their assembly and disassembly, mechanical properties, polarity, and the type of molecular motors associated with them. Earlier, they were thought to be present only in eukaryotic cells; however, their...
24.8K
Cytoplasm01:24

Cytoplasm

6.8K
The cytoplasm consists of organelles and a framework of protein scaffolds called the cytoskeleton suspended in an aqueous solution, the cytosol. The cytosol is a rich broth of water, ions, salts, and various organic molecules.
Protein Folding and Misfolding
The cytoplasm is the location for several cellular processes, including protein synthesis and folding. The aqueous nature of the cytosol promotes protein folding such that the hydrophobic amino acid side chains are buried in the protein...
6.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Management of transfusion-dependent β-thalassaemia in the era of novel therapies: a prioritisation-based matrix for settings with limited resources.

The Lancet. Haematology·2026
Same author

TNFα signaling restores steady-state hematopoiesis in a TNFαKO mouse model of anemia of inflammation.

Blood·2025
Same author

Effective gene therapy for metachromatic leukodystrophy achieved with minimal lentiviral genomic integrations.

Molecular therapy. Nucleic acids·2025
Same author

CD47 peptide-cloaked lipid nanoparticles promote cell-specific mRNA delivery.

Molecular therapy : the journal of the American Society of Gene Therapy·2025
Same author

Selecting patients with sickle cell disease for gene addition or gene editing-based therapeutic approaches: Report on behalf of a joint EHA Specialized Working Group and EBMT Hemoglobinopathies Working Party consensus conference.

HemaSphere·2025
Same author

Restoring hematopoietic stem and progenitor cell function in <i>Fancc</i> <sup></sup> mice by <i>in situ</i> delivery of RNA lipid nanoparticles.

Molecular therapy. Nucleic acids·2025
Same journal

Decentralized Clinical Trials in Hematology: the Promise and the Peril.

Blood·2026
Same journal

How I Treat Chemotherapy-Induced Thrombocytopenia with Thrombopoietin Receptor Agonists.

Blood·2026
Same journal

The Chaos of Choice in Large B-cell Lymphoma: A Call to Harmonize First-line Trial Design.

Blood·2026
Same journal

Precision Transfusion Medicine in the Omics Era.

Blood·2026
Same journal

Fibrocytes drive JAK2V617F-mutated myelofibrosis: pitavastatin reverses marrow fibrosis and anemia.

Blood·2026
Same journal

Identifying steroid-refractory aGVHD before it happens.

Blood·2026
See all related articles

Related Experiment Video

Updated: May 3, 2026

Author Spotlight: Investigating the Motion Dynamics of the Eukaryotic Replisome Components at the Single-Molecule Level
10:11

Author Spotlight: Investigating the Motion Dynamics of the Eukaryotic Replisome Components at the Single-Molecule Level

Published on: July 26, 2024

1.6K

Enucleate or replicate? Ask the cytoskeleton.

Stefano Rivella1

  • 1WEILL CORNELL MEDICAL COLLEGE.

Blood
|February 1, 2014
PubMed
Summary
This summary is machine-generated.

Tropomodulin-3 (Tmod-3) plays a key role in red blood cell development. This study reveals its novel functions in erythroid proliferation, survival, and enucleation.

More Related Videos

Biophysical Assays to Probe the Mechanical Properties of the Interphase Cell Nucleus: Substrate Strain Application and Microneedle Manipulation
16:27

Biophysical Assays to Probe the Mechanical Properties of the Interphase Cell Nucleus: Substrate Strain Application and Microneedle Manipulation

Published on: September 14, 2011

12.2K
Imaging Replicative Domains in Ultrastructurally Preserved Chromatin by Electron Tomography
14:56

Imaging Replicative Domains in Ultrastructurally Preserved Chromatin by Electron Tomography

Published on: May 20, 2022

3.3K

Related Experiment Videos

Last Updated: May 3, 2026

Author Spotlight: Investigating the Motion Dynamics of the Eukaryotic Replisome Components at the Single-Molecule Level
10:11

Author Spotlight: Investigating the Motion Dynamics of the Eukaryotic Replisome Components at the Single-Molecule Level

Published on: July 26, 2024

1.6K
Biophysical Assays to Probe the Mechanical Properties of the Interphase Cell Nucleus: Substrate Strain Application and Microneedle Manipulation
16:27

Biophysical Assays to Probe the Mechanical Properties of the Interphase Cell Nucleus: Substrate Strain Application and Microneedle Manipulation

Published on: September 14, 2011

12.2K
Imaging Replicative Domains in Ultrastructurally Preserved Chromatin by Electron Tomography
14:56

Imaging Replicative Domains in Ultrastructurally Preserved Chromatin by Electron Tomography

Published on: May 20, 2022

3.3K

Area of Science:

  • Hematology
  • Cell Biology
  • Molecular Biology

Background:

  • Actin filament organization is crucial for red blood cell development.
  • Tropomodulin proteins are known regulators of actin dynamics.

Purpose of the Study:

  • To investigate the role of Tropomodulin-3 (Tmod-3) in erythroid cells.
  • To elucidate Tmod-3's functions in erythroid proliferation, survival, and enucleation.

Main Methods:

  • The study likely involved in vitro erythroid differentiation models.
  • Analysis of Tmod-3 expression and function in developing red blood cells.

Main Results:

  • Sui and colleagues identified novel roles for Tmod-3 in erythroid cells.
  • Tmod-3 is involved in regulating actin organization during erythropoiesis.
  • Tmod-3 impacts erythroid cell proliferation, survival, and the enucleation process.

Conclusions:

  • Tropomodulin-3 is a significant protein in red blood cell maturation.
  • Understanding Tmod-3's function provides insights into hematological disorders.