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Related Concept Videos

Disorders of Erythrocytes01:27

Disorders of Erythrocytes

2.7K
Disorders of erythrocytes, or red blood cells (RBCs), include a range of conditions affecting their number, shape, or function.
Erythrocyte disorders can be broadly categorized into two main types: anemic and polycythemic conditions.
A low oxygen-carrying capacity of the blood due to the loss, lower production, or destruction of erythrocytes is termed anemia. Hemorrhagic anemia, for example, occurs when bleeding from an external wound or internal ulcer reduces erythrocyte counts.
On the other...
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Overview of Hematopoiesis01:20

Overview of Hematopoiesis

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Hematopoiesis, or blood cell production, is a vital biological process that begins early in embryonic development and continues throughout life. This process generates the various types of cells found in blood, including red blood cells, white blood cells, and platelets from hematopoietic stem cells (HSCs).
Developmental Phases of Hematopoiesis
Initially, HSCs are formed in the embryonic yolk sac, a critical site for early blood cell production. These stem cells subsequently migrate to other...
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Factors Affecting Erythropoiesis01:24

Factors Affecting Erythropoiesis

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The cardiovascular system regulates the number of erythrocytes in the bloodstream to ensure optimal oxygen transport. It also prevents over-proliferation of these cells, which helps to maintain blood viscosity and flow rate.
Several factors influence the erythrocyte production rate, with tissue oxygen level being among the most critical. Intense exercise or high altitudes can cause tissue hypoxia, which triggers the kidneys to release more erythropoietin (EPO) into the bloodstream.
EPO then...
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Erythropoiesis01:14

Erythropoiesis

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Red blood cells  (RBCs) transport oxygen to all body tissues. These cells survive only for 120 days and then need to be replenished. Erythropoiesis is the process of RBC production. In healthy individuals, erythropoiesis ensures all tissues are amply supplied with oxygen. In addition, blood loss due to injury leads to a drop in the physiological oxygen level that will cause erythropoiesis. Any defect in erythropoiesis leads to several physiological disorders, including thalassemia, anemia,...
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Erythropoiesis01:14

Erythropoiesis

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Hematopoiesis01:21

Hematopoiesis

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The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
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Related Experiment Video

Updated: May 3, 2026

Author Spotlight: Developing a Point-of-Care Hemoglobin Estimation Method for Anemia Management
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Author Spotlight: Developing a Point-of-Care Hemoglobin Estimation Method for Anemia Management

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Anemia: a comprehensive global estimate.

Sant-Rayn Pasricha1

  • 1UNIVERSITY OF OXFORD;

Blood
|February 1, 2014
PubMed
Summary

Anemia affected 32.9% of the global population in 2010, causing over 68 million years lived with disability (YLD). This highlights anemia

Area of Science:

  • Hematology
  • Global Health
  • Epidemiology

Background:

  • Anemia is a significant global health concern with substantial disease burden.
  • Understanding the precise prevalence and disability impact of anemia is crucial for public health initiatives.

Purpose of the Study:

  • To estimate the global prevalence of anemia in 2010.
  • To quantify the years lived with disability (YLD) attributable to anemia worldwide.

Main Methods:

  • Utilized data from Kassebaum et al. published in Blood.
  • Estimated global anemia prevalence for the year 2010.
  • Calculated the global burden of disease in terms of YLD.

Main Results:

  • Global anemia prevalence in 2010 was estimated at 32.9%.

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Measurement of Tissue Non-Heme Iron Content using a Bathophenanthroline-Based Colorimetric Assay
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Determining Gender-Based Differences in Retinal and Choroidal Thickness in Underweight Individuals via Swept-Source Optical Coherence Tomography
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Determining Gender-Based Differences in Retinal and Choroidal Thickness in Underweight Individuals via Swept-Source Optical Coherence Tomography

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Measurement of Tissue Non-Heme Iron Content using a Bathophenanthroline-Based Colorimetric Assay
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  • Anemia contributed to 68.4 million years lived with disability (YLD) globally.
  • The findings underscore anemia's significant role in the overall global burden of disease.

    • Conclusions:

    • Anemia represents a major contributor to the global burden of disease.
    • The study's findings warrant increased attention and resource allocation to address anemia.
    • Effective interventions are needed to reduce the global impact of anemia.