Related Experiment Video
Updated: May 3, 2026
Characterization of a Pathogenic Escherichia coli Strain Derived from Oreochromis spp. Farms Using Whole-Genome Sequencing
Published on: December 23, 2022
Complete Genome Sequence of Ehrlichia muris Strain AS145T, a Model Monocytotropic Ehrlichia Strain
Nagaraja R Thirumalapura1, Xiang Qin, Jeeba A Kuriakose
1Department of Pathology, University of Texas Medical Branch, Galveston, Texas, USA.
Abstract:
We report here the complete genome sequence of Ehrlichia muris strain AS145(T), which was isolated from a wild mouse in 1983 in Japan. E. muris establishes persistent infections in laboratory mice and is widely used as a surrogate pathogen in a murine model of ehrlichiosis.
Insights
We sequenced the complete genome of Ehrlichia muris strain AS145(T), a pathogen used in mouse models of ehrlichiosis. This provides a foundational resource for understanding this persistent bacterial infection.
Area of Science:
- Microbiology
- Genomics
- Infectious Diseases
Background:
- Ehrlichia muris is a bacterial pathogen known to establish persistent infections in laboratory mice.
- The bacterium is frequently utilized as a surrogate pathogen in murine models of ehrlichiosis, aiding research into the disease.
- Understanding the genetic makeup of E. muris is crucial for advancing research in tick-borne diseases.
Purpose of the Study:
- To report the complete genome sequence of Ehrlichia muris strain AS145(T).
- To provide a genomic resource for the study of E. muris and ehrlichiosis.
- To facilitate further research utilizing E. muris in murine models.
Main Methods:
- Whole-genome sequencing of Ehrlichia muris strain AS145(T).
- Bioinformatic analysis of the obtained genome sequence.
Main Results:
- The complete genome sequence of Ehrlichia muris strain AS145(T) has been determined.
- The genome sequence provides a comprehensive genetic blueprint of the pathogen.
Conclusions:
- The availability of the complete genome sequence of E. muris strain AS145(T) is a significant advancement for the field.
- This genomic data will support future investigations into E. muris pathogenesis and host-pathogen interactions.
- Researchers can now leverage this resource for enhanced studies in murine models of ehrlichiosis.
