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Related Experiment Video

Updated: May 3, 2026

Gasless Endoscopic Thyroidectomy via the Trans-Axillary Approach
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Does adrenaline spraying over thyroidectomy area reduce bleeding?

Yeliz E Ersoy1, Erhan Aysan1, Aysenur Meric2

  • 1Department of General Surgery, Faculty of Medicine, Bezmialem Vakif University 34306 Vatan Caddesi, Fatih, Istanbul, Turkey.

International Journal of Clinical and Experimental Medicine
|February 1, 2014
PubMed
Summary

Adrenaline spraying significantly reduced post-thyroidectomy drainage. This method shows promise for controlling bleeding and potentially eliminating the need for drains after thyroidectomy surgery.

Keywords:
Adrenalinebleedinghematomathyroidthyroidectomy

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Area of Science:

  • Surgical Oncology
  • Endocrine Surgery
  • Minimally Invasive Surgery

Background:

  • Postoperative bleeding and hematoma formation are significant concerns in thyroidectomy.
  • Effective methods for intraoperative and postoperative bleeding control are crucial for patient safety and outcomes.
  • Adrenaline's potential role in reducing bleeding and drainage after thyroidectomy requires further investigation.

Purpose of the Study:

  • To evaluate the efficacy of adrenaline spraying in controlling bleeding during and after total thyroidectomy.
  • To assess the impact of adrenaline application on reducing postoperative drainage volume and hematoma formation.
  • To determine if adrenaline spraying can obviate the need for surgical drains in thyroidectomy patients.

Main Methods:

  • A randomized clinical trial involving 80 patients undergoing total thyroidectomy.
  • The intervention group (n=40) received topical adrenaline (1 mg/ml in 10 ml saline) spray to the surgical site.
  • The control group (n=40) underwent standard total thyroidectomy without adrenaline application. Drainage amounts were recorded over 24 hours.

Main Results:

  • Patients receiving adrenaline spray demonstrated statistically significant lower daily drainage volumes compared to the control group (p<0.05).
  • Thyroid gland volume was significantly correlated with drainage amounts in both the adrenaline (+) and (-) groups (p=0.008 and p<0.001, respectively).
  • No specific data on hematoma formation was detailed, but reduced drainage suggests a potential decrease.

Conclusions:

  • Topical adrenaline application appears to be a promising adjunct in thyroidectomy, potentially reducing hemorrhage and drainage.
  • The preliminary findings suggest that adrenaline spraying may allow for the omission of surgical drains.
  • Further prospective, randomized trials with larger patient cohorts are necessary to confirm the efficacy and safety of adrenaline use in thyroid surgery.