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Updated: May 3, 2026

Fine-tuning the Size and Minimizing the Noise of Solid-state Nanopores
Published on: October 31, 2013
Escape of DNA from a weakly biased thin nanopore: experimental evidence for a universal diffusive behavior
David P Hoogerheide1, Fernando Albertorio1, Jene A Golovchenko2
1Department of Physics, Harvard University, Cambridge, Massachusetts 02138, USA.
Abstract:
We report experimental escape time distributions of double-stranded DNA molecules initially threaded halfway through a thin solid-state nanopore. We find a universal behavior of the escape time distributions consistent with a one-dimensional first passage formulation notwithstanding the geometry of the experiment and the potential role of complex molecule-liquid-pore interactions. Diffusion constants that depend on the molecule length and pore size are determined. Also discussed are the practical implications of long time diffusive molecule trapping in the nanopore.
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