Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Multiple Sclerosis l: Introduction01:19

Multiple Sclerosis l: Introduction

20
Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...
20
Brain Imaging01:14

Brain Imaging

1.0K
Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
1.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Profiling the long-term risk of severe adverse events in a cohort of multiple sclerosis patients treated with different treatment sequences: Results from the Italian Multiple Sclerosis and Related Disorders Registry (I-MS&RD) (ProSA study).

Multiple sclerosis (Houndmills, Basingstoke, England)·2026
Same author

Targeting shared immune pathways in multiple sclerosis and type 1 diabetes: Therapeutic insights from monoclonal antibodies.

Autoimmunity reviews·2026
Same author

Use of High-Efficacy Therapy in Children With Multiple Sclerosis to Prevent Long-Term Disability.

Neurology·2026
Same author

Clinical, structural, and functional MRI features predicting PIRMA at 5-year follow-up in multiple sclerosis.

Multiple sclerosis (Houndmills, Basingstoke, England)·2026
Same author

Long-term safety and efficacy of ponesimod in participants with relapsing multiple sclerosis: results from the phase 3 OPTIMUM 5-year long term extension study.

Journal of neurology·2026
Same author

A proof-of-concept study on the relationship between lifetime Estrogen exposure, menopausal transition, and neurodegeneration in women with multiple sclerosis.

Journal of the neurological sciences·2026
Same journal

Erratum for: Prediction of Lobar Emphysema Progression with a CT-Based Foundational Model.

Radiology·2026
Same journal

Erratum for: Associations of MRI-derived Paraspinal IMAT and LMM with Cardiometabolic Risk Factors: Results from a German Cohort.

Radiology·2026
Same journal

Erratum for: Blue Rubber Bleb Nevus Syndrome.

Radiology·2026
Same journal

Redefining the Clinical Role of MRI in Endometrial Cancer Staging.

Radiology·2026
Same journal

To Ablate or Not to Ablate: The Colorectal Liver Metastasis Question.

Radiology·2026
Same journal

The Limits of Radiologic Categorization in Pulmonary Nonsolid Nodules.

Radiology·2026
See all related articles

Related Experiment Video

Updated: May 3, 2026

A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy
08:23

A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy

Published on: November 13, 2016

10.1K

Multiple sclerosis: altered thalamic resting-state functional connectivity and its effect on cognitive function.

Francesca Tona1, Nikolaos Petsas, Emilia Sbardella

  • 1From the Department of Neurology and Psychiatry, Sapienza University of Rome, Viale dell'Università 30, 00185 Rome, Italy; and IRCCS Neuromed, Pozzilli, Italy (P.P.).

Radiology
|February 4, 2014
PubMed
Summary
This summary is machine-generated.

Resting-state functional connectivity in multiple sclerosis (MS) patients is disrupted, particularly in the thalamus. Cognitive impairment correlates with altered thalamocortical functional connectivity, suggesting neuroplasticity cannot overcome tissue damage.

More Related Videos

Measuring and Manipulating Functionally Specific Neural Pathways in the Human Motor System with Transcranial Magnetic Stimulation
09:52

Measuring and Manipulating Functionally Specific Neural Pathways in the Human Motor System with Transcranial Magnetic Stimulation

Published on: February 23, 2020

8.8K
Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity
10:43

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity

Published on: July 1, 2014

14.1K

Related Experiment Videos

Last Updated: May 3, 2026

A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy
08:23

A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy

Published on: November 13, 2016

10.1K
Measuring and Manipulating Functionally Specific Neural Pathways in the Human Motor System with Transcranial Magnetic Stimulation
09:52

Measuring and Manipulating Functionally Specific Neural Pathways in the Human Motor System with Transcranial Magnetic Stimulation

Published on: February 23, 2020

8.8K
Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity
10:43

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity

Published on: July 1, 2014

14.1K

Area of Science:

  • Neuroimaging
  • Neurology
  • Cognitive Neuroscience

Background:

  • Multiple Sclerosis (MS) is a demyelinating disease affecting the central nervous system.
  • Cognitive impairment is a common and disabling symptom in MS patients.
  • Thalamocortical pathways are crucial for cognitive functions and are implicated in MS.

Purpose of the Study:

  • To investigate thalamocortical functional connectivity (FC) using resting-state functional magnetic resonance (MR) imaging in MS.
  • To examine the correlation between altered FC and cognitive impairment in MS.
  • To understand the role of neuroplasticity in compensating for MS-related tissue damage.

Main Methods:

  • Utilized resting-state (RS) functional MR imaging and diffusion-tensor imaging in 48 MS patients and 24 controls.
  • Performed neuropsychological testing using the Paced Auditory Serial Addition Test (PASAT).
  • Analyzed functional MR imaging data using seed-based methods to identify the thalamic resting-state network (RSN).

Main Results:

  • MS patients exhibited gray and white matter atrophy and diffusion-tensor imaging abnormalities compared to controls.
  • Patients showed altered synchronization in various brain regions, including decreased synchronization in the thalamus.
  • Cognitive performance (PASAT scores) significantly correlated with thalamic and other regional FC, with stronger correlations for shorter task durations.

Conclusions:

  • Thalamic resting-state networks are disrupted in multiple sclerosis.
  • Increased thalamocortical functional connectivity is associated with cognitive deficits in MS.
  • Neuroplasticity appears insufficient to fully compensate for tissue damage and prevent cognitive dysfunction in MS.