Related Experiment Video
Updated: May 3, 2026

Lethality Bioassay Using Artemia salina L.
Published on: October 11, 2022
Cytotoxic clerodane diterpenes from Zuelania guidonia
Carlos Calderón1, Christian De Ford, Victor Castro
1Escuela de Quimica and CIPRONA, Universidad de Costa Rica , 2060 San José, Costa Rica.
Abstract:
The leaves of Zuelania guidonia yielded eight new clerodane diterpenes, namely, zuelaguidins A-H (1-8), and the known clerodane diterpene esculentin A (9). Some of these structures contained a 3,6-dihydro-1,2-dioxin moiety. The new compounds were isolated and identified using 1D- and 2D-NMR experiments. All compounds were evaluated for cytotoxicity against the CCRF-CEM (human acute lymphocytic leukemia), CEM-ADR5000 (human acute lymphocytic leukemia resistant to doxorubicin), and MIA-PaCa-2 (human pancreatic carcinoma) cell lines as well as for their selectivity against peripheral blood mononuclear cells from healthy human subjects. Zuelaguidins B, C, and E were the most potent compounds against the CCRF-CEM cell line, with IC50 values ranging from 1.6 to 2.5 μM.
More Related Videos
08:22Author Spotlight: A New and Efficient Method for Comprehensive Metabolite Cytotoxicity Assessment of Triazole Pesticides in Plants
Published on: December 22, 2023
07:59A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
Related Concept Videos
Cytotoxic Edema: Pathophysiology
Cytotoxic T Cells-mediated Immune Response
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Diphtheria
Hypersensitivity Reactions: Cytolytic Reactions
Aryldiazonium Salts to Azo Dyes: Diazo Coupling
Fungal Group Zygomycota