Related Experiment Video
Updated: May 3, 2026

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
Published on: January 19, 2016
Recent progress in asymmetric fluorination and trifluoromethylation reactions
Vincent Bizet, Tatiana Besset, Jun-An Ma
1UMR 6014 COBRA, CNRS, Université de Rouen et INSA de Rouen, Rue Tesniere, F-76821 Mont-Saint- Aignan Cedex, France. dominique.cahard@univ-rouen.fr.
Abstract:
All domains of society are impacted by fluorine chemistry. In particular, fluorine plays a key role in medicinal, pharmaceutical and agrochemical sciences in which the synthesis and evaluation of molecules featuring one or more fluorine atoms is nowadays routine in every new discovery and development program. Since the beginning of this century, enantiopure fluorinated molecules are at the forefront of innovation of the tremendous achievements in fluorine chemistry. This review introduces the reader to the recent progress in asymmetric installation of one fluorine and a trifluoromethyl group via nucleophilic, electrophilic and radical diastereo- and enantioselective reactions.
More Related Videos
10:10Application of Elemental Lanthanides in the Selective C-F Activation of Trifluoromethylated Benzofulvenes Providing Access to Various Difluoroalkenes
Published on: July 28, 2018
09:58Metal-free Synthesis of Ynones from Acyl Chlorides and Potassium Alkynyltrifluoroborate Salts
Published on: February 24, 2015
Related Concept Videos
Electrophilic Aromatic Substitution: Fluorination and Iodination of Benzene
Preparation of 1° Amines: Hofmann and Curtius Rearrangement Overview
Base-Promoted α-Halogenation of Aldehydes and Ketones
Preparation and Reactions of Sulfides
Conversion of Alcohols to Alkyl Halides
Diazonium Group Substitution with Halogens and Cyanide: Sandmeyer and Schiemann Reactions