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The acute phase response in gout.

R Roseff1, J R Wohlgethan, J D Sipe

  • 1Medical Service, Boston Veterans Administration Medical Center, MA 02130.

The Journal of Rheumatology
|October 1, 1987
PubMed
Summary
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Gout triggers an acute phase response, indicated by elevated inflammatory markers like C-reactive protein (CRP) and serum amyloid A protein (SAA). This response, linked to joint inflammation, quickly resolves with treatment.

Area of Science:

  • Rheumatology
  • Immunology
  • Clinical Medicine

Background:

  • Gout is a form of inflammatory arthritis characterized by the deposition of monosodium urate crystals in joints.
  • The body's acute phase response is a systemic reaction to inflammation or tissue damage.

Purpose of the Study:

  • To investigate the acute phase response in patients with gout.
  • To determine the correlation between the severity of gout and specific acute phase reactants.

Main Methods:

  • Measurements included oral temperature, white blood cell count and differential, platelet count, Westergren erythrocyte sedimentation rate (ESR), serum amyloid A protein (SAA), and C-reactive protein (CRP).
  • Correlations were analyzed between the number of involved joints and inflammatory markers.
  • Correlations were also examined between C-reactive protein (CRP) levels and other measured parameters.

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Main Results:

  • Elevated levels of oral temperature, white blood cell count, platelet count, ESR, SAA, and CRP were observed in gout patients.
  • The number of involved joints showed a positive correlation with ESR, SAA, and CRP levels.
  • CRP levels were found to correlate with temperature, differential white blood cell count, ESR, and SAA.

Conclusions:

  • Gout elicits a significant acute phase response.
  • The extent of joint involvement in gout correlates with the intensity of the acute phase response.
  • The acute phase response in gout is rapidly reversible upon effective treatment.