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Updated: May 3, 2026
Testing the Efficacy of Pharmacological Agents in a Pericardial Target Delivery Model in the Swine
Published on: July 7, 2016
Epicardial ablation performance of a novel radiofrequency device on the beating heart in pigs
Yoshiyuki Watanabe1, Timo Weimar1, Toshinobu Kazui1
1Division of Cardiothoracic Surgery, Department of Surgery, Washington University School of Medicine, Barnes-Jewish Hospital, St. Louis, Missouri.
Purpose:
Only bipolar clamps create reliable transmural lesions on the beating heart. This study evaluated the performance of a new radiofrequency (RF) device on the beating heart in an acute porcine model.
Description:
Six domestic pigs were ablated with a novel bipolar RF linear device on the beating heart (ablation time of 40 s, 3 each on right and left atria and 1 each on superior and inferior vena cavae). The heart was stained with 2, 3, 5-triphenyl-tetrazolium chloride, and each lesion was cross-sectioned for lesion depth and transmurality.
Evaluation:
Transmurality was documented in 89% of the cross-sections. Sixty-three percent of lesions were transmural along the entire lesion length. Overall, 85% of the nontransmural cross-sections were located on the right atrium, and half of the nontransmural sections were in the superior or inferior vena cavae lesions.
Conclusions:
This novel device was able to create transmural lesions on the beating heart, more effectively in the left atrium than in the right atrium.
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