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Updated: May 3, 2026

Mass Spectrometry-Guided Genome Mining as a Tool to Uncover Novel Natural Products
Published on: March 12, 2020
Recent advances and new strategies in the NMR-based identification of natural products
Maria Halabalaki1, Konstantina Vougogiannopoulou1, Emmanuel Mikros1
1Division of Medicinal and Natural Products Chemistry, Department of Pharmacy, University of Athens, Panepistimiopolis Zografou, 15771 Athens, Greece.
Abstract:
Nature comprises an untapped pool of unique compounds with high structural uniqueness and exceptional properties. At the core of natural products (NPs) discovery is the identification procedure and NMR remains the most efficient method. Technical improvements such as miniaturized and crycogenic NMR probes along with hyphenation capabilities and computational support are at the center of evolution. Concepts such as dereplication and metabolomics are increasingly adopted in NPs using the power of databases, currently fragmented. The introduction and utilization of these technical and computational implements could lead NPs research to more comprehensive structure identification and new holistic perspectives.
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