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iChip

iChip

The cultivation of environmental microorganisms has long been hindered by the inability to replicate complex native conditions in vitro. The isolation chip (iChip) addresses this limitation by facilitating the growth of previously uncultivable microorganisms through in situ incubation. Designed for high-throughput microbial cultivation, the iChip comprises hundreds of microchambers, each capable of housing a single microbial cell. These microchambers are loaded with a mixture of molten agar and...

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Updated: May 3, 2026

Generation of a Human iPSC-Based Blood-Brain Barrier Chip

Generation of a Human iPSC-Based Blood-Brain Barrier Chip

Published on: March 2, 2020

Human-on-chip for therapy development and fundamental science.

Camilla Luni¹, Elena Serena¹, Nicola Elvassore¹

¹Department of Industrial Engineering, University of Padova, Via Marzolo 9, 35131 Padova, Italy; Venetian Institute of Molecular Medicine, Via Orus 2, 35129 Padova, Italy.

Current Opinion in Biotechnology

|February 4, 2014

Summary

Organ-on-chip systems use microfluidics and living cells as human in vitro models, offering a promising alternative to animal testing for studying physiology and disease. Different cell sources, like biopsies and stem cells, suit specific research needs.

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Area of Science:

Biotechnology
Cell Biology
Microfluidics

Background:

Organ-on-chip systems integrate microfluidic technology with living cells to model human physiology and pathophysiology.
These human in vitro models offer a promising alternative to animal testing.
Their small scale allows precise control and high-throughput experiments not feasible macroscopically.

Purpose of the Study:

To explore the use of various biological materials in organ-on-chip development.
To highlight the suitability of different cell sources for specific applications in disease modeling and physiological studies.
To discuss the technical requirements for integrating diverse biological materials into microfluidic chips.

Main Methods:

Utilizing microfluidic technology to create organ-on-chip systems.
Culturing and integrating diverse biological materials, including biopsies, induced pluripotent stem cells, and primary cultures.
Analyzing the specific applications and technical requirements for each biological material source.

Main Results:

Biopsies are ideal for studying age-related physiological changes.
Induced pluripotent stem cells show promise for investigating genetic disease pathogenesis.
Primary cultures can effectively bridge gaps in organ-on-chip applications.

Conclusions:

The choice of biological material is critical for the success of organ-on-chip models.
Different cell sources offer unique advantages for studying specific aspects of human health and disease.
Organ-on-chip technology, with tailored material sourcing, advances in vitro human modeling.