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Related Concept Videos

Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

395
Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
395
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

354
In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
354
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

367
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
367
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

861
As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
861
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

382
Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are...
382
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

400
Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...
400

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Related Experiment Videos

Ethnogeriatrics in critical care.

Sonya R Hardin1

  • 1East Carolina University, College of Nursing, 600 Moye Boulevard, Greenville, NC 27858, USA.

Critical Care Nursing Clinics of North America
|February 4, 2014
PubMed
Summary

The number of diverse older adults in intensive care units will rise. Integrating ethnogeriatric assessments is crucial for culturally sensitive and effective patient care.

Area of Science:

  • Geriatrics
  • Critical Care Medicine
  • Sociology

Background:

  • The demographic landscape of intensive care units (ICUs) is shifting, with an anticipated increase in the diversity of older adult patients over the next decade.
  • Current critical care practices may not adequately address the unique cultural and ethnic needs of this growing patient population.

Purpose of the Study:

  • To highlight the growing diversity among older adults requiring intensive care.
  • To emphasize the necessity of incorporating ethnogeriatric principles into critical care.
  • To outline key components of a comprehensive ethnogeriatric assessment for ICU settings.

Main Methods:

  • Discussion of demographic trends in aging and critical care.
  • Review of existing literature on ethnogeriatrics and cultural competence.
Keywords:
CultureDiversityEthnicityEthnogeriatrics

Related Experiment Videos

  • Conceptual framework for integrating ethnogeriatric assessment into ICU protocols.

    • Main Results:

    • Projected increase in ethnic and cultural diversity among older ICU patients.
    • Identification of critical assessment domains including ethnicity, acculturation, and spirituality.
    • Recognition of communication and physical examination challenges related to cultural factors.

    Conclusions:

    • Ethnogeriatric assessment is essential for providing equitable and effective care to diverse older adults in the ICU.
    • Healthcare providers must adapt assessment and care strategies to accommodate cultural nuances.
    • Proactive integration of these principles will improve patient outcomes and reduce health disparities.