Related Experiment Video
Updated: May 3, 2026
08:21
A Modified Two Kidney One Clip Mouse Model of Renin Regulation in Renal Artery Stenosis
Published on: October 26, 2020
4.9K
[Renin-angiotensin system and urological cancers]
G Verhoest1, T Dolley-Hitze2, F Jouan3
1Service d'urologie, CHU de Rennes, 2, rue Henri-Le-Guilloux, 35033 Rennes, France; CNRS UMR6290/Biosit, faculté de médecine, université Rennes 1, 2, avenue du Professeur-Léon-Bernard, CS 34317, 35043 Rennes cedex, France.
Summary
The renin-angiotensin system (RAS) plays a role in cancer development. Blocking this system shows anti-tumor effects and may improve cancer treatment outcomes.
Area of Science:
- Oncology
- Molecular Biology
- Urology
Background:
- The renin-angiotensin system (RAS) role in tumorigenesis is debated.
- RAS involvement in cancer, particularly urological cancers, requires clarification.
Purpose of the Study:
- To systematically review the literature on RAS involvement in cancer.
- To assess the potential of RAS blockers as anti-cancer agents.
Main Methods:
- Systematic review of PubMed-indexed articles.
- Keywords: cancer, renin, angiotensin, VEGF, AT1R, RAS blockers.
Main Results:
- AT1-R is overexpressed in various human cancers.
- Angiotensin-II promotes neoangiogenesis and cell proliferation.
- RAS blockers demonstrated anti-tumoral efficacy in preclinical models.
- Retrospective patient studies suggest improved survival and treatment response with RAS blockers.
Conclusions:
- Evidence suggests RAS involvement in carcinogenesis.
- RAS blockers show promise as adjuncts to cancer therapy.
- Further clinical trials are needed to confirm these findings.
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