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Updated: Feb 14, 2026

Visualization, Quantification, and Mapping of Immune Cell Populations in the Tumor Microenvironment
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Visualization, Quantification, and Mapping of Immune Cell Populations in the Tumor Microenvironment

Published on: March 25, 2020

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Sensitizing protective tumor microenvironments to antibody-mediated therapy

Christian P Pallasch1, Ilya Leskov2, Christian J Braun2

  • 1Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Internal Medicine, Center of Integrated Oncology, University of Cologne, Cologne 50931, Germany.

Cell
|February 4, 2014
PubMed
Summary

Chemotherapy can enhance antibody therapy by altering the tumor microenvironment. Cyclophosphamide induces cytokines that promote macrophage activity, improving the immune system's ability to eliminate leukemia cells.

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