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An elevated pro-inflammatory cytokine profile in multiple chemical sensitivity.
T M Dantoft1, J Elberling1, S Brix2
1The Danish Research Centre for Chemical Sensitivities, Department of Dermato-Allergology, Copenhagen University Hospital Gentofte, Gentofte, Denmark.
Psychoneuroendocrinology
|February 4, 2014
Summary
Multiple chemical sensitivity (MCS) patients show altered immune responses. Increased pro-inflammatory cytokines and specific Th2-associated cytokines suggest low-grade systemic inflammation in MCS individuals.
Area of Science:
- Immunology
- Environmental Health
Background:
- Multiple Chemical Sensitivity (MCS) is a medically unexplained condition.
- Its pathophysiology may involve immune system dysregulation.
Purpose of the Study:
- To compare plasma cytokine levels in Danish MCS patients versus healthy controls.
- To investigate potential immune system involvement in MCS.
Main Methods:
- Collected plasma from 150 MCS patients and 148 controls.
- Measured 14 cytokines, chemokines, growth factors, and allergen-specific IgE.
- Administered questionnaires on MCS, psychological distress, and health status.
Main Results:
- MCS patients had significantly higher levels of IL-1β, IL-2, IL-4, and IL-6.
- Tumor necrosis factor-α was borderline significantly increased.
- Interleukin-13 levels were significantly decreased in MCS patients.
Conclusions:
- MCS individuals exhibit a unique immune mediator profile.
- Elevated pro-inflammatory cytokines and altered Th2-associated cytokines suggest low-grade systemic inflammation.
- The deviating Th2 response in MCS does not appear to involve IgE-mediated mechanisms.
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