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Bronchial hyperreactivity in children with antibody deficiencies
Celal Özcan1, Ayşe Metin1, Mustafa Erkoçoğlu1
1Ankara Children's Hematology Oncology, Education and Research Hospital, Department of Pediatric Allergy and Immunology, Ankara, Turkey.
Allergologia Et Immunopathologia
|February 4, 2014
Summary
Bronchial hyperreactivity (BHR) is common in antibody deficiencies, particularly selective IgA deficiency. This study highlights the increased prevalence of BHR in specific antibody deficiency groups, suggesting a link between immune dysfunction and airway hyperresponsiveness.
Area of Science:
- Immunology
- Pulmonology
- Allergy & Clinical Immunology
Background:
- Antibody deficiencies are characterized by impaired antibody responses to pathogens.
- Asthma and allergic diseases are frequently observed in individuals with antibody deficiencies.
- Limited data exist on bronchial hyperreactivity (BHR) across various antibody deficiency types.
Purpose of the Study:
- To evaluate and compare the frequency of BHR in patients with different types of antibody deficiencies.
- To investigate the association between specific antibody deficiencies and the presence of BHR.
Main Methods:
- A cohort of 113 patients aged 5-18 with diagnosed antibody deficiencies underwent assessment.
- Patient histories of asthma and allergies were collected, alongside allergic skin prick tests.
- Methacholine challenge tests were performed to assess BHR, with complete blood counts and serum IgE levels measured.
Main Results:
- The study included diverse antibody deficiencies, with selective IgA deficiency being the most prevalent (41.6%).
- Overall, 42.5% of patients exhibited BHR upon methacholine challenge.
- BHR was significantly more frequent in patients with selective IgA deficiency and partial IgA deficiency compared to IgG subclass deficiency.
Conclusions:
- Bronchial hyperreactivity is prevalent in patients with antibody deficiencies.
- Selective IgA deficiency is associated with a higher incidence of BHR compared to IgG subclass deficiency.
- These findings underscore the importance of evaluating airway hyperresponsiveness in individuals with antibody deficiencies.
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