Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Cerebral Hemispheres

Cerebral Hemispheres

The human brain, a complex organ, is functionally divided into two cerebral hemispheres—left and right. These hemispheres are interconnected by a structure of paramount importance, the corpus callosum. This substantial bundle of neural fibers is not just a bridge between the hemispheres but a crucial element for the brain's comprehensive functioning. It enables efficient communication between the two hemispheres, allowing each side of the brain to control and receive sensory and motor...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Fatigue relief is possible.

Frontiers in integrative neuroscience·2026

Same author

Fatigue relief: the contribution of non-invasive neuromodulation (FAREviaNM).

Frontiers in neuroscience·2026

Same author

Pediatric acute respiratory distress syndrome in children with type I - spinal muscular atrophy: a 12-year case series.

European journal of pediatrics·2025

Same author

Increased Callosal Thickness in Early Trained Opera Singers.

Brain topography·2025

Same author

Large-scale analysis of structural brain asymmetries during neurodevelopment: Associations with age and sex in 4265 children and adolescents.

Human brain mapping·2024

Same author

BILATERAL CAROTID BODY PARAGANGLIOMAS - LITERATURE REVIEW AND COMMENTS IN A PATIENT WITH NO SIGNS OF MEN SYNDROME.

Acta endocrinologica (Bucharest, Romania : 2005)·2023

Search research articles

Related Experiment Video

Updated: Jan 4, 2026

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Published on: July 19, 2019

Inter-hemispheric functional connectivity changes with corpus callosum morphology in multiple sclerosis.

G Zito¹, E Luders², L Tomasevic¹

¹Laboratory of Electrophysiology for Translational neuroScience (LET'S), ISTC, Consiglio Nazionale delle Ricerche, 'S. Giovanni Calibita' Fatebenefratelli Hospital, Rome I-00186, Italy; Department of Clinical Neuroscience, AFaR, 'San Giovanni Calibita' Fatebenefratelli Hospital, Rome I-00186, Italy.

|February 4, 2014

Summary

This summary is machine-generated.

Early multiple sclerosis (MS) shows subtle brain changes. Structural corpus callosum (CC) thinning correlates with reduced inter-hemispheric coherence (IHCoh), indicating early network dysfunction in MS patients.

Keywords:

corpus callosum electroencephalography/event-related potentials (EEG/ERPs)inter-hemispheric coherence relapsing-remitting multiple sclerosis (RRMS)sensorimotor control structural magnetic resonance imaging

More Related Videos

Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy

Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy

Published on: August 5, 2014

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Published on: July 28, 2013

Related Experiment Videos

Last Updated: Jan 4, 2026

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Published on: July 19, 2019

Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy

Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy

Published on: August 5, 2014

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Published on: July 28, 2013

Area of Science:

Neuroscience
Neuroimmunology
Medical Imaging

Background:

Multiple sclerosis (MS) is a central nervous system disorder impacting myelin.
MS leads to brain atrophy, neurodegeneration, and functional disconnections.
Early detection of connectivity alterations is crucial for MS management.

Purpose of the Study:

To investigate early structural and functional connectivity changes in MS.
To correlate corpus callosum (CC) morphology with inter-hemispheric connectivity (IHCoh).
To identify covert impairments in mildly disabled relapsing-remitting MS (RR-MS) patients.

Main Methods:

Structural MRI measured CC thickness in 100 sections.
Electroencephalography (EEG) assessed spectral coherence index (IHCoh) between motor regions.
20 RR-MS patients (EDSS ≤ 3.5) and 15 healthy controls were studied at rest and during handgrip.

Main Results:

CC atrophy in MS patients correlated with increased lesion load.
Reduced IHCoh during movement linked to CC atrophy in motor areas (anterior mid-body).
In controls, reduced IHCoh at rest correlated with a thinner CC splenium.

Conclusions:

Mildly disabled RR-MS patients exhibit covert impairments in CC structure-function correlation.
Structural CC thinning and functional IHCoh deficits are linked, even before individual measures differ from controls.
This suggests early network-level dysfunction in early MS.