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Cyclic nucleotides may mediate taste transduction.

K Tonosaki¹, M Funakoshi

¹Department of Oral Physiology, School of Dentistry, Asahi University, Gifu, Japan.

|January 28, 1988

Summary

Intracellular recordings in mouse taste cells reveal that cyclic nucleotides and calcium ions may control taste perception by modulating potassium channels. This suggests a mechanism similar to vision and smell transduction.

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Area of Science:

Neuroscience
Sensory Biology
Molecular Biology

Background:

Taste stimulus adsorption occurs at the taste cell microvillous membrane.
Technical challenges hinder intracellular recordings in mammalian taste cells, limiting understanding of taste transduction mechanisms.

Purpose of the Study:

To investigate the intracellular mechanisms of taste transduction in mammalian taste cells.
To determine the role of cyclic nucleotides and calcium ions in taste cell signaling.

Main Methods:

Performed intracellular recordings in mouse taste cells.
Electrophoretically injected cyclic AMP, cyclic GMP, EGTA, and tetraethyl-ammonium into taste cells.

Main Results:

Injected substances induced membrane depolarization and increased membrane resistance in taste cells.
Results suggest a cyclic nucleotide enzymatic cascade, modulated by calcium ions, controls potassium permeability.

Conclusions:

A cyclic nucleotide enzymatic cascade, modulated by calcium, likely mediates potassium permeability in taste transduction.
The identified mechanism is analogous to transduction processes in vision and olfaction.

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