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Degradation of connexins and gap junctions
Matthias M Falk1, Rachael M Kells1, Viviana M Berthoud2
1Department of Biological Sciences, Lehigh University, 111 Research Drive, Iacocca Hall, D-218, Bethlehem, PA 18015, USA.
FEBS Letters
|February 4, 2014
Summary
Connexin proteins have short lifespans and are degraded via multiple cellular pathways. This review details the signals and interactions guiding connexin and gap junction degradation.
Area of Science:
- Cell Biology
- Protein Degradation
- Molecular Mechanisms
Background:
- Connexin proteins form gap junctions, crucial for intercellular communication.
- These proteins are inherently unstable, with short intracellular half-lives.
- Protein degradation pathways significantly influence connexin levels.
Purpose of the Study:
- To review the degradation mechanisms of connexins.
- To identify signals and protein interactions involved in connexin degradation.
- To consolidate current knowledge on connexin and gap junction turnover.
Main Methods:
- Literature review of studies on connexin degradation.
- Analysis of proteasomal, endo-/lysosomal, and phago-/lysosomal pathways.
- Identification of key regulatory signals and protein partners.
Main Results:
- Connexins are degraded through distinct pathways at various assembly stages.
- Proteasomal, endo-/lysosomal, and phago-/lysosomal routes are implicated.
- Specific signals and protein-protein interactions target connexins for degradation.
Conclusions:
- Connexin degradation is a complex, multi-pathway process.
- Understanding these pathways is key to modulating connexin function.
- Targeting degradation mechanisms offers potential therapeutic avenues.
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