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Cortical Thickness Changes Associated with Photoparoxysmal Response.

Alexandru Hanganu^1,2, Stanislav A Groppa², Günther Deuschl¹

¹Clinic of Neurology, University Hospital Schleswig-Holstein, University of Kiel, Kiel, Germany.

Brain Topography

|February 4, 2014

Summary

Photoparoxysmal response (PPR), an epilepsy trait, shows altered cortical thickness in the occipital, frontal, and temporal lobes. These structural changes correlate with functional alterations observed in previous studies.

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Area of Science:

Neuroimaging
Epilepsy Research
Human Brain Anatomy

Background:

Photoparoxysmal response (PPR) is an electroencephalogram (EEG) trait linked to idiopathic generalized epilepsy (IGE).
Previous research indicated functional brain alterations in occipital and frontal cortices associated with PPR.
The current study aimed to investigate the structural brain changes related to PPR.

Purpose of the Study:

To determine structural brain changes, specifically cortical thickness, associated with photoparoxysmal response (PPR).
To compare cortical thickness in individuals with PPR, individuals with PPR and IGE, and healthy controls.

Main Methods:

T1-weighted magnetic resonance imaging (MRI) was used to analyze cortical thickness.
Three groups were compared: PPR-positive subjects, PPR-positive idiopathic generalized epilepsy (IGE) patients, and PPR-negative healthy controls (HC).

Main Results:

PPR-positive subjects showed increased cortical thickness in bilateral occipital, frontal, and parietal regions compared to HC.
PPR-positive subjects exhibited decreased cortical thickness in the temporal cortex compared to HC.
IGE patients displayed reduced cortical thickness in the temporal lobe and right paracentral region compared to PPR-positive subjects.

Conclusions:

Structural changes in the occipital, frontoparietal, and temporal lobes are associated with PPR.
These structural alterations complement previously identified functional changes linked to PPR.
Epilepsy patients demonstrate specific cortical thickness changes in the temporal lobe and supplementary motor area.