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Related Concept Videos

Brain Imaging01:14

Brain Imaging

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Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
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Epilepsy and Seizures: Overview01:24

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Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
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A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy
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Neuroimaging the epileptogenic process.

Sandy R Shultz1, Terence J O'Brien, Maria Stefanidou

  • 1Department of Medicine, The Melbourne Brain Centre, The Royal Melbourne Hospital, The University of Melbourne, Building 144, Royal Parade, Parkville, VIC, 3010, Australia, sshultz@unimelb.edu.au.

Neurotherapeutics : the Journal of the American Society for Experimental Neurotherapeutics
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PubMed
Summary

Neuroimaging advances epilepsy research by revealing early disease changes and monitoring treatment effectiveness. This non-invasive tool is crucial for developing new therapies to combat epileptogenesis.

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Area of Science:

  • Neurology
  • Neuroscience
  • Medical Imaging

Background:

  • Epilepsy is a common chronic neurological disorder affecting millions globally.
  • Current anti-epileptic drugs (AEDs) manage seizures but do not cure epilepsy or halt its progression.
  • Developing disease-modifying therapies requires understanding epileptogenesis and identifying reliable biomarkers.

Purpose of the Study:

  • To provide an overview of neuroimaging studies investigating epileptogenesis.
  • To highlight the role of neuroimaging in understanding early pathophysiological changes.
  • To assess the potential of neuroimaging for monitoring disease progression and therapy effectiveness.

Main Methods:

  • Review of studies utilizing various neuroimaging modalities.
  • Analysis of research conducted in both animal models of epilepsy and human patients.
  • Focus on non-invasive neuroimaging techniques.

Main Results:

  • Neuroimaging can identify early pathophysiological changes associated with epileptogenesis.
  • Different neuroimaging modalities offer insights into the epilepsy disease process.
  • These techniques show promise for tracking disease progression and evaluating treatment efficacy.

Conclusions:

  • Neuroimaging is a vital non-invasive tool for epilepsy research.
  • Understanding epileptogenesis through neuroimaging is key to developing curative therapies.
  • Further research utilizing neuroimaging can accelerate the development of disease-modifying interventions for epilepsy.