DHF characterized by acute type DIC with increased vascular permeability.

Area of Science:

• Hematology
• Infectious Diseases
• Pathophysiology

Background:

• Dengue Hemorrhagic Fever (DHF) is a severe mosquito-borne viral infection.
• Understanding the early pathophysiological changes in DHF is crucial for timely intervention.
• Disseminated Intravascular Coagulation (DIC) is a complex syndrome that can complicate severe infections.

Purpose of the Study:

• To investigate the hematological and coagulation parameters in patients with Dengue Hemorrhagic Fever (DHF) at the early fever stage.
• To identify potential indicators of acute Disseminated Intravascular Coagulation (DIC) in DHF.
• To explore the relationship between early DHF manifestations and vascular permeability.

Main Methods:

• Observational study of patients diagnosed with DHF grade II.
• Transient monitoring of platelet count, fibrinogen concentration, factor VIII, antithrombin III, and alpha 2-antiplasmin activities.
• Analysis of Fibrin Degradation Products (FDP-D) fraction and assessment for pleural effusion.

Main Results:

• Transient decreases were observed in platelet count, fibrinogen concentration, factor VIII, antithrombin III, and alpha 2-antiplasmin activities.
• An increase in the FDP-D fraction was noted.
• Pleural effusion was transiently observed in the early fever stage.

Conclusions:

• The observed changes indicate manifestations consistent with acute Disseminated Intravascular Coagulation (DIC) in early-stage DHF grade II.
• These findings suggest increased permeability of the vascular wall during the initial fever phase of DHF.
• Early detection of DIC markers may aid in managing DHF complications.