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Transient Middle Cerebral Artery Occlusion Model of Neonatal Stroke in P10 Rats
Published on: April 21, 2017
Factors affecting cognitive outcome in early pediatric stroke
Martina Studer1, Eugen Boltshauser, Andrea Capone Mori
1From University Children's Hospital Berne (M. Studer, E.W., T.H., M. Steinlin); Center for Cognition, Learning and Memory (M. Studer, T.H., M. Steinlin), University of Berne; University Children's Hospital Zürich (E.B., A.H.); Children's Hospital Aarau (A.C.M.); University Children's Hospital Basel (A.D.); University Children's Hospital Geneva (J.F.); Children's Hospital Neuchâtel (D.M.); Children's Hospital Chur (E.K.); Children's Hospital St. Gallen (O.M.); Children's Hospital Sion (J.-P.M.); Children's Hospital Bellinzona (G.-P.R.); University Children's Hospital Lausanne (C.P.); Children's Hospital Winterthur (R.S.); and Children's Hospital Lucerne (T.S.-M.), Switzerland.
Children with arterial ischemic stroke (AIS) often have lower cognitive performance, especially in memory and processing speed. Young age at stroke, seizures, and lesion location are risk factors for poorer cognitive outcomes.
Area of Science:
- Pediatric Neurology
- Neuropsychology
- Developmental Neuroscience
Background:
- Pediatric arterial ischemic stroke (AIS) can significantly impact cognitive development.
- Understanding factors influencing cognitive outcomes is crucial for early intervention.
Purpose of the Study:
- To examine cognitive performance in children following AIS.
- To identify risk factors influencing cognitive outcomes, including age at stroke, seizures, lesion characteristics, neurologic impairment (NI), and functional outcome.
Main Methods:
- Prospective study of 99 children with AIS (age 1 month to 16 years).
- Cognitive and neurologic assessments conducted 2 years post-stroke using age-appropriate instruments.
Main Results:
- Mean cognitive performance was in the lower normative range.
- Poorer performance observed in visuoconstructive skills, short-term memory, and processing speed.
- Risk factors for negative cognitive outcomes included young age at stroke, seizures, combined cortical and subcortical lesions, and marked NI.
Conclusions:
- Children with AIS frequently exhibit deficits in specific cognitive domains.
- Early and regular neuropsychological assessment is recommended for children with AIS.
- Timely interventions and environmental adjustments are vital for optimizing cognitive development.
Related Concept Videos
Ischemic Stroke ll: Pathophysiology
Information Processing Approach
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