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Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
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Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
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Complement C3c as a biomarker in heart failure.

A Frey1, G Ertl1, C E Angermann1

  • 1Department of Internal Medicine I, University Hospital Würzburg, Oberdürrbacher Straße 6, 97080 Würzburg, Germany ; Comprehensive Heart Failure Center, University of Würzburg, Straubmühlweg 2a, Haus A9, 97078 Würzburg, Germany.

Mediators of Inflammation
|February 4, 2014
PubMed
Summary
This summary is machine-generated.

Elevated C3c complement levels in heart failure (HF) patients may indicate better survival and less adverse cardiac remodeling. This finding suggests C3c could be a useful prognostic marker in stable systolic HF.

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Area of Science:

  • Immunology
  • Cardiology
  • Biomarkers

Background:

  • The innate immune system, particularly complement, plays a role in cardiac remodeling and heart failure (HF).
  • Complement-deficient animals show protection against adverse cardiac remodeling.
  • Peripheral complement levels are hypothesized as potential markers for HF prognosis.

Purpose of the Study:

  • To investigate the association between peripheral complement levels and adverse remodeling/prognosis in patients with stable systolic HF.
  • To evaluate serum C3c as a potential biomarker in heart failure.

Main Methods:

  • Serum C3c levels were measured in 197 patients with stable systolic HF.
  • Patients were subgrouped based on normal versus elevated C3c levels.
  • Clinical parameters including survival, LVEF, NTpro-BNP, and comorbidities were analyzed.

Main Results:

  • Elevated C3c levels were observed in 17% of the HF cohort.
  • Patients with elevated C3c showed a trend towards better survival, higher LVEF, and lower NTpro-BNP.
  • Elevated C3c was associated with a higher prevalence of preexisting diabetes but not other common HF comorbidities.

Conclusions:

  • Elevated serum C3c levels are linked to less adverse cardiac remodeling in stable systolic heart failure.
  • Higher C3c levels correlate with improved survival outcomes in this patient group.
  • C3c shows potential as a prognostic biomarker for heart failure.